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Recovery of stem cells from cryopreserved periodontal ligament

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dc.contributor.authorSeo, B-M-
dc.contributor.authorMiura, M-
dc.contributor.authorSonoyama, W-
dc.contributor.authorCoppe, C-
dc.date.accessioned2010-07-23T03:18:22Z-
dc.date.available2010-07-23T03:18:22Z-
dc.date.issued2005-10-
dc.identifier.citationJournal of Dental Research 84:907-912en
dc.identifier.issn0022-0345-
dc.identifier.urihttps://hdl.handle.net/10371/68674-
dc.description.abstractHuman post-natal stem cells possess a great potential to be utilized in stem-cell-mediated clinical therapies and tissue engineering. It is not known whether cryopreserved human tissues contain functional post-natal stem cells. In this study, we utilized human periodontal ligament to test the hypothesis that cryopreserved human periodontal ligament contains retrievable post-natal stem cells. These cryopreserved periodontal ligament stem cells maintained normal periodontal ligament stem cell characteristics, including expression of the mesenchymal stem cell surface molecule STRO-1, single-colony-strain generation, multipotential differentiation, cementum/periodontal-ligament-like tissue regeneration, and a normal diploid karyotype. Collectively, this study provides valuable evidence demonstrating a practical approach to the preservation of solid-frozen human tissues for subsequent post-natal stem cell isolation and tissue regeneration. The present study demonstrates that human post-natal stem cells can be recovered from cryopreserved human periodontal ligament, thereby providing a practical clinical approach for the utilization of frozen tissues for stem cell isolation.en
dc.language.isoenen
dc.publisherAmerican and International Associations for Dentalen
dc.subjectperiodontal ligament stem cells(PDLSCs)en
dc.subjectosteoblasten
dc.subjectcementumen
dc.subjectcryopreservationen
dc.titleRecovery of stem cells from cryopreserved periodontal ligamenten
dc.typeArticleen
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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