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Anti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis model

DC Field Value Language
dc.contributor.authorChang, Sun-Hwa-
dc.contributor.authorChoi, Youngnim-
dc.contributor.authorPark, Jung-Ae-
dc.contributor.authorJung, Dong-Sik-
dc.contributor.authorShin, Jieun-
dc.contributor.authorYang, Ji-Hyun-
dc.contributor.authorKo, Seon-Yle-
dc.contributor.authorKim, Se-Won-
dc.contributor.authorKim, Jung-Keun-
dc.date.accessioned2010-08-02-
dc.date.available2010-08-02-
dc.date.issued2007-12-
dc.identifier.citationClin Nutr. 2007;26(6):785-791en
dc.identifier.issn0261-5614-
dc.identifier.urihttp://hdl.handle.net/10371/68818-
dc.description.abstractBackground & aims
Although there has been some success with protein-based anti-tumor necrosis factor α (TNF-α) therapeutics, the problems associated with protein-based drugs demand alternative approaches. We screened various herbal extracts for their ability to inhibit TNF-α secretions and found that BT-201, an n-butanol extract of Panax notoginseng (Burk.) F. H. Chen (P. notoginseng) has such an ability.

Methods
The purpose of this study has been to evaluate the anti-inflammatory and anti-rheumatic effects of BT-201. The anti-inflammatory effects were evaluated by measuring the effects of BT-201 on the production of TNF-α, interleukin (IL)-1β, inducible nitric oxide (iNO), and matrix metalloproteinase-13 (MMP-13), in vitro. The anti-rheumatic effects were evaluated by treating mice with collagen-induced arthritis (CIA) using a daily oral administration of BT-201 at 15 mg/kg/day. In addition, the effects on NF-κB and mitogen-activated protein kinase (MAPK) pathways were evaluated by Western blotting using phospho-specific antibodies.

Results
BT-201 significantly inhibited all the inflammatory parameters evaluated in vitro and delayed the onset and progression of CIA. BT-201 inhibited the activation of NF-κB, ERK, p38, and JNK pathways.

Conclusions
Our results demonstrated that BT-201 can modulate various aspects of inflammation in vitro and that it has disease-modifying, anti-rheumatic effects in vivo, suggesting that it can be a potential alternative to the current anti-TNF-α therapeutics for rheumatoid arthritis and other inflammatory disease.
en
dc.description.sponsorshipThis work was supported by a grant from the Korean Ministry
of Commerce, Industry and Energy. Some of this work was
performed using facilities of the Oscotec Inc. Dr. Youngnim
Choi contributed to writing of the manuscript and analysis of
data. Other authors (Dr. Seon-Yle Ko, Dr. Se-Won Kim, and
Dr. Jung-Keun Kim) contributed to analysis of data and
provision of significant advice.
en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectPanax notoginsengen
dc.subjectArthritisen
dc.subjectTNF-αen
dc.subjectNF-κBen
dc.subjectMAPKen
dc.titleAnti-inflammatory effects of BT-201, an n-butanol extract of Panax notoginseng, observed in vitro and in a collagen-induced arthritis modelen
dc.typeArticleen
dc.contributor.AlternativeAuthor장선화-
dc.contributor.AlternativeAuthor최영님-
dc.contributor.AlternativeAuthor박정애-
dc.contributor.AlternativeAuthor정동식-
dc.contributor.AlternativeAuthor신지은-
dc.contributor.AlternativeAuthor양지현-
dc.contributor.AlternativeAuthor고선일-
dc.contributor.AlternativeAuthor김세원-
dc.contributor.AlternativeAuthor김정근-
dc.identifier.doi10.1016/j.clnu.2007.07.008-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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