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APP processing and synaptic plasticity in presenilin-1 conditional knockout mice.

Cited 203 time in Web of Science Cited 217 time in Scopus
Issue Date
2001-09-13
Publisher
Elsevier
Citation
Neuron 31, 713–726
Abstract
We have developed a presenilin-1 (PS1) conditional knockout mouse (cKO), in which PS1 inactivation is restricted to the postnatal forebrain. The PS1 cKO mouse is viable and exhibits no gross abnormalities. The carboxy-terminal fragments of the amyloid precursor protein differentially accumulate in the cerebral cortex of cKO mice, while generation of β-amyloid peptides is reduced. Expression of Notch downstream effector genes, Hes1, Hes5, and Dll1, is unaffected in the cKO cortex. Although basal synaptic transmission, long-term potentiation, and long-term depression at hippocampal area CA1 synapses are normal, the PS1 cKO mice exhibit subtle but significant deficits in long-term spatial memory. These results demonstrate that inactivation of PS1 function in the adult cerebral cortex leads to reduced Aβ generation and subtle cognitive deficits without affecting expression of Notch downstream genes.
ISSN
0896-6273
Language
English
URI
https://hdl.handle.net/10371/68824
DOI
https://doi.org/10.1016/S0896-6273(01)00417-2
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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