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Design and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesion

DC Field Value Language
dc.contributor.authorKim, Tae-Il-
dc.contributor.authorJang, Jun-Hyeog-
dc.contributor.authorLee, Yong-Moo-
dc.contributor.authorRyu, In-Cheol-
dc.contributor.authorChung, Chong-Pyoung-
dc.contributor.authorHan, Soo-Boo-
dc.contributor.authorChoi, Sang-Mook-
dc.contributor.authorKu, Young-
dc.date.accessioned2010-08-02T01:15:23Z-
dc.date.available2010-08-02T01:15:23Z-
dc.date.issued2002-
dc.identifier.citationBiotechnology Letters 24: 2029–2033en
dc.identifier.issn0141-5492-
dc.identifier.urihttps://hdl.handle.net/10371/68835-
dc.description.abstractA synthetic oligopeptide, composed of Arg-Gly-Asp (RGD) and its synergistic Pro-His-Ser-Arg-Asn (PHSRN)
motifs and a six glycines (G6) linker, promoted human osteoblast-like cell (MG-63) adhesion, spreading and
mitogen-activated protein kinase (MAPK) activity in a similar manner to a positive fibronectin control. This
synthetic oligopeptide may therefore be a useful osteo-inductive material.
en
dc.description.sponsorshipThis work was supported by the Korean Science and
Engineering Foundation (KOSEF) through the Intellectual
Biointerface Engineering Center (IBEC) at
Seoul National University.
en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectfibronectinen
dc.subjectmitogen-activated protein kinaseen
dc.subjectoligopeptidesen
dc.subjectosteoblast-like cellen
dc.titleDesign and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesionen
dc.typeArticleen
dc.contributor.AlternativeAuthor김태일-
dc.contributor.AlternativeAuthor장준형-
dc.contributor.AlternativeAuthor이용무-
dc.contributor.AlternativeAuthor류인철-
dc.contributor.AlternativeAuthor정종평-
dc.contributor.AlternativeAuthor한수부-
dc.contributor.AlternativeAuthor최상묵-
dc.contributor.AlternativeAuthor구영-
dc.identifier.doi10.1023/A:1021368519336-
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