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Biological efficacy of silk fibroin nanofiber membranes for guided bone regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyoung-Hwa | - |
dc.contributor.author | Jeong, Lim | - |
dc.contributor.author | Park, Ho-Nam | - |
dc.contributor.author | Shin, Seung-Yun | - |
dc.contributor.author | Park, Won-Ho | - |
dc.contributor.author | Lee, Sang-Chul | - |
dc.contributor.author | Kim, Tae-Il | - |
dc.contributor.author | Park, Yoon-Jeong | - |
dc.contributor.author | Seol, Yang-Jo | - |
dc.contributor.author | Lee, Yong-Moo | - |
dc.contributor.author | Ku, Young | - |
dc.contributor.author | Rhyu, In-Chul | - |
dc.contributor.author | Han, Soo-Boo | - |
dc.contributor.author | Chung, Chong-Pyoung | - |
dc.date.accessioned | 2010-08-03T23:48:23Z | - |
dc.date.available | 2010-08-03T23:48:23Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of Biotechnology 120, 327–339 | en |
dc.identifier.issn | 0168-1656 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68910 | - |
dc.description.abstract | The favorable biological properties of silk fibroin (SF) nanofiber membrane make it a good candidate for clinical applications
as a device in bone and periodontal regenerative therapy. The purpose of this study is to evaluate the biocompatibility of the SF nanofiber membrane, and to examine its effect on bone regeneration in a rabbit calvarial model. To examine the biocompatibility of the electrospun SF membrane, we investigated cell proliferation, morphology, and differentiation. The bone regenerative efficacy of the membrane was evaluated in the calvarial defect of rabbits. The cell numbers and osteocalcin production labels were significantly increased in accordance with culture period. Cells had a stellate shape and broad cytoplasmic extensions on the membrane. The cells showed activity of ALPase that was comparable to culture dishes, and were calcified similarly to culture dishes. In in vivo tests, a complete bony union across the defects was observed after 8 weeks. At 12 weeks, the defect had completely healed with new bone. In conclusion, the SF nanofiber membrane was shown to possess good biocompatibility with enhanced bone regeneration and no evidence of any inflammatory reaction. These results strongly suggest that the SF membrane should be useful as a tool for guided bone regeneration. | en |
dc.description.sponsorship | This work was supported by the grant from Korea
Science and Engineering Foundation (KOSEF) through Intellectual Biointerface Engineering Center (IBEC) at Seoul National University, Seoul, Korea. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Silk fibroin | en |
dc.subject | Nanofiber | en |
dc.subject | Membrane | en |
dc.subject | Guided bone regeneration | en |
dc.title | Biological efficacy of silk fibroin nanofiber membranes for guided bone regeneration | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김경화 | - |
dc.contributor.AlternativeAuthor | 정임 | - |
dc.contributor.AlternativeAuthor | 박호남 | - |
dc.contributor.AlternativeAuthor | 신승윤 | - |
dc.contributor.AlternativeAuthor | 박원호 | - |
dc.contributor.AlternativeAuthor | 이상철 | - |
dc.contributor.AlternativeAuthor | 김태일 | - |
dc.contributor.AlternativeAuthor | 박윤정 | - |
dc.contributor.AlternativeAuthor | 설양조 | - |
dc.contributor.AlternativeAuthor | 이용무 | - |
dc.contributor.AlternativeAuthor | 구영 | - |
dc.contributor.AlternativeAuthor | 류인철 | - |
dc.contributor.AlternativeAuthor | 한수부 | - |
dc.contributor.AlternativeAuthor | 정종평 | - |
dc.identifier.doi | 10.1016/j.jbiotec.2005.06.033 | - |
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