Browse

Pre-clinical Models for Oral and Periodontal Reconstructive Therapies

DC Field Value Language
dc.contributor.authorSeol, YJ-
dc.contributor.authorPellegrini, G-
dc.contributor.authorGruber, R-
dc.contributor.authorGiannobile, WV-
dc.date.accessioned2010-08-04T22:49:58Z-
dc.date.available2010-08-04T22:49:58Z-
dc.date.issued2009-
dc.identifier.citationJournal of Dental Research 88:1065-1076en
dc.identifier.issn0022-0345-
dc.identifier.urihttps://hdl.handle.net/10371/68963-
dc.description.abstractThe development of new medical formulations (NMF) for reconstructive therapies has considerably improved the available treatment options for individuals requiring periodontal repair or oral implant rehabilitation. Progress in tissue engineering and regenerative medicine modalities strongly depends on validated pre-clinical research. Pre-clinical testing has contributed to the recent approval of NMF such as GEM 21 S ® and INFUSE ® bone grafts for periodontal and oral regenerative therapies. However, the selection of a suitable pre-clinical model for evaluation of the safety and efficacy of a NMF remains a challenge. This review is designed to serve as a primer to choose the appropriate pre-clinical models for the evaluation of NMF in situations requiring periodontal or oral reconstruction. Here, we summarize commonly used pre-clinical models and provide examples of screening and functional studies of NMF that can be translated into clinical use.en
dc.description.sponsorshipThis
research was supported by NIH/NIDCR DE13397 and by the AO
Foundation Biotechnology Advisory Council (Davos, Switzerland).
en
dc.language.isoenen
dc.publisherAmerican and International Associations for Dentalen
dc.titlePre-clinical Models for Oral and Periodontal Reconstructive Therapiesen
dc.typeArticleen
dc.identifier.doi10.1177/0022034509349748-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse