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Wound healing effect of silk fibroin/alginate-blended sponge in full thickness skin defect of rat
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Roh, Dae-Hyun | - |
dc.contributor.author | Kang, Seuk-Yun | - |
dc.contributor.author | Kim, Jeom-Yong | - |
dc.contributor.author | Kwon, Young-Bae | - |
dc.contributor.author | Kweon, Hae Young | - |
dc.contributor.author | Lee, Kwang-Gill | - |
dc.contributor.author | Park, Young-Hwan | - |
dc.contributor.author | Baek, Rong-Min | - |
dc.contributor.author | Heo, Chan-Yeong | - |
dc.contributor.author | Choe, Joon | - |
dc.contributor.author | Lee, Jang-Hern | - |
dc.date.accessioned | 2009-08-11T03:57:22Z | - |
dc.date.available | 2009-08-11T03:57:22Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | J. Mater. Sci. Mater. Med. 17 (2006) 547 | en |
dc.identifier.issn | 0957-4530 (print) | - |
dc.identifier.issn | 1573-4838 (oine) | - |
dc.identifier.uri | https://hdl.handle.net/10371/6916 | - |
dc.description.abstract | Silk fibroin (SF) and alginate (AA) have been proved to be invaluable natural materials in the field of biomedical engineering. This study was designed to compare the wound healing effect of SF, AA and SF/AA-blended sponge (SF/AA) with clinically used Nu GauzeTM (CONT) in a rat full thickness wound model. Two circular skin wounds on the back of rat were covered with either of CONT, SF, AA or SF/AA. On the postoperative days of 3, 7, 10 and 14, residual wound area was calculated, and skin wound tissues were biopsied to measure the area of regenerated epithelium and collagen deposition as well as the number of proliferating cell nuclear antigen (PCNA)-immunoreactive cells. Half healing time (HT50) of SF/AA was dramatically reduced as compared with that of SF, AA or CONT. Furthermore, SF/AA significantly increased the size of re-epithelialization and the number of PCNA positive cells, whereas the effect of SF/AA on collagen deposition was not significantly different as compared with that of SF or AA. These results demonstrate that the wound healing effect of SF/AA is the best among other treatments including SF and AA, and this synergic effect is mediated by re-epithelialization via rapid proliferation of epithelial cell. | en |
dc.description.sponsorship | Thisworkwas supported by grant No. R01-2002-
000-00391-0 from the Basic Research Program of the Korea Science & Engineering Foundation. In addition, the publication of this manuscript was supported by the BrainKorea 21 project in the College ofVeterinary Medicine and School of Agricultural Biotechnology, Seoul National University. | en |
dc.language.iso | en | - |
dc.publisher | Springer Verlag | en |
dc.title | Wound healing effect of silk fibroin/alginate-blended sponge in full thickness skin defect of rat | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 노대현 | - |
dc.contributor.AlternativeAuthor | 강석윤 | - |
dc.contributor.AlternativeAuthor | 김점용 | - |
dc.contributor.AlternativeAuthor | 권영배 | - |
dc.contributor.AlternativeAuthor | 권해용 | - |
dc.contributor.AlternativeAuthor | 이광길 | - |
dc.contributor.AlternativeAuthor | 박영환 | - |
dc.contributor.AlternativeAuthor | 백롱민 | - |
dc.contributor.AlternativeAuthor | 허찬영 | - |
dc.contributor.AlternativeAuthor | 이장헌 | - |
dc.identifier.doi | 10.1007/s10856-006-8938-y | - |
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