Browse

Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma.

DC Field Value Language
dc.contributor.authorHong, Sam-Pyo-
dc.contributor.authorLee, Jae-Il-
dc.contributor.authorJin, Bo-Hyong-
dc.contributor.authorKim, Mi-Ae-
dc.contributor.authorYoon, Hye-Jung-
dc.contributor.authorHong, Seong-Doo-
dc.date.accessioned2010-09-03T01:11:38Z-
dc.date.available2010-09-03T01:11:38Z-
dc.date.issued2009-05-
dc.identifier.citationOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 2009;107:678-684en
dc.identifier.issn1079-2104-
dc.identifier.urihttps://hdl.handle.net/10371/69617-
dc.description.abstractObjective
We investigated the prognostic significance of CXC chemokine receptor CXCR-4 expression in patients with oral squamous cell carcinoma (OSCC) and its relationship with matrix metalloproteinase 2 (MMP-2), MMP-9, and Ki-67 expression.

Study design
The CXCR-4, MMP-2, MMP-9, and Ki-67 expression was assessed immunohistochemically in 74 OSCC patients. The results were analyzed in connection with clinicopathologic factors.

Results
The CXCR-4 expression was positive in 45 cases and significantly correlated with lymph node metastasis (P = .037), MMP-9 expression (P = .025), and Ki-67 expression (P = .001). Univariate analysis showed that CXCR-4 expression, MMP-9 expression, Ki-67 expression, tumor size, lymph node metastasis, clinical stage, and recurrence positively correlated with prognosis. Multivariate analysis indicated that CXCR-4 expression was an independent prognostic factor for poor survival in patients with OSCC.

Conclusion
Expression of CXCR-4 is a significant prognostic indicator for poor survival in patients with OSCC and correlates with expression of MMP-9 and Ki-67. The inhibition of CXCR-4 represents a possible molecular approach to the treatment of OSCC.
en
dc.language.isoenen
dc.publisherElsevieren
dc.titlePrognostic significance of CXCR-4 expression in oral squamous cell carcinoma.en
dc.typeArticleen
dc.contributor.AlternativeAuthor홍삼표-
dc.contributor.AlternativeAuthor이재일-
dc.contributor.AlternativeAuthor진보형-
dc.contributor.AlternativeAuthor김미애-
dc.contributor.AlternativeAuthor연혜정-
dc.contributor.AlternativeAuthor홍성두-
dc.identifier.doi10.1016/j.tripleo.2008.12.047-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse