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The effecet of UNCL inactivation on the expression of mechanical stress related genes in cultured human PDL fibroblasts

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dc.contributor.authorPark, Joo-Cheol-
dc.contributor.authorChoi, Yong-Seok-
dc.contributor.authorJang, Hyun-Sun-
dc.contributor.authorLee, Dong-Seol-
dc.contributor.authorKim, Heung-Joong-
dc.contributor.authorPark, Jong-Tae-
dc.contributor.authorBae, Hyun-Sook-
dc.date.accessioned2010-09-03T01:14:47Z-
dc.date.available2010-09-03T01:14:47Z-
dc.date.issued2008-06-31-
dc.identifier.citationInternational Journal of Oral Biology, 33(2): 51-58en
dc.identifier.issn1226-7155-
dc.identifier.urihttps://hdl.handle.net/10371/69619-
dc.description.abstractA mutation of UNCL, an inner nuclear membrane RNAbinding
protein, has been found to eliminate mechanotransduction
in Drosophila. UNCL is expressed in human
periodontal tissue including in periodontal ligament (PDL)
fibroblasts. However, it is unclear how a mechanical
stimulus is translated into cellular responses in PDL
fibroblasts. The aim of this study was to evaluate the effect
of UNCl on mechanical stress related genes in PDL
fibroblasts in response to mechanical stress. The mRNA of
TGF-β, COX-2, and MMP-2 was up-regulated after UNCL
inactivation in PDL fibroblasts under the compression
force. Under the tensile force, inactivation of UNCL
decreased the expression of Biglycan, RANKL, MMP-2,
and TIMP-2 mRNAs while it increased the expression of
TIMP-1. p38-MAPK was expressed in PDL fibroblasts
under compression forces whereas phospho-ERK1/2, p65-
NFkB, and c-fos were expressed under tension forces. The
expression and phosphorylation of the mechanical stress
related genes, kinases, and transcription factors were
changed according to the types of stress. Furthermore, most
of them were regulated by the inactivation of UNCL. This
suggests that UNCL is involved in the regulation of
mechanical stress related genes through the signaling
pathway in PDL fibroblasts.
en
dc.language.isoenen
dc.publisherKorean Acadamy of Oral Biologyen
dc.subjectUNCLen
dc.subjectMechanical stressen
dc.subjectPDL fibroblasten
dc.subjectInactivationen
dc.titleThe effecet of UNCL inactivation on the expression of mechanical stress related genes in cultured human PDL fibroblastsen
dc.typeArticleen
dc.contributor.AlternativeAuthor박주철-
dc.contributor.AlternativeAuthor최용석-
dc.contributor.AlternativeAuthor장현순-
dc.contributor.AlternativeAuthor이동설-
dc.contributor.AlternativeAuthor김형종-
dc.contributor.AlternativeAuthor박종태-
dc.contributor.AlternativeAuthor배현숙-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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