Publications
Detailed Information
SHED repair critical-size calvarial defects in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, BM | - |
dc.contributor.author | Sonoyama, W | - |
dc.contributor.author | Yamaza, T | - |
dc.contributor.author | Coppe, C | - |
dc.contributor.author | Kikuiri, T | - |
dc.contributor.author | Akiyama, K | - |
dc.contributor.author | Lee, JS | - |
dc.contributor.author | Shi, S | - |
dc.date.accessioned | 2010-09-03T05:39:28Z | - |
dc.date.available | 2010-09-03T05:39:28Z | - |
dc.date.issued | 2008-06 | - |
dc.identifier.citation | Oral Diseases 14: 428-434 | en |
dc.identifier.issn | 1354-523X | - |
dc.identifier.uri | https://hdl.handle.net/10371/69657 | - |
dc.description.abstract | Objective: Stem cells from human exfoliated deciduous teeth (SHED) are a population of highly proliferative postnatal stem cells capable of differentiating into odontoblasts, adipocytes, neural cells, and osteo-inductive cells. To examine whether SHED-mediated bone regeneration can be utilized for therapeutic purposes, we used SHED to repair critical-size calvarial defects in immunocompromised mice.
Materials and methods: We generated calvarial defects and transplanted SHED with hydroxyapatite/tricalcium phosphate as a carrier into the defect areas. Results: SHED were able to repair the defects with substantial bone formation. Interestingly, SHED-mediated osteogenesis failed to recruit hematopoietic marrow elements that are commonly seen in bone marrow mesenchymal stem cell-generated bone. Furthermore, SHED were found to co-express mesenchymal stem cell marker, CC9/MUC18/CD146, with an array of growth factor receptors such as transforming growth factor β receptor I and II, fibroblast growth factor receptor I and III, and vascular endothelial growth factor receptor I, implying their comprehensive differentiation potential. Conclusions: Our data indicate that SHED, derived from neural crest cells, may select unique mechanisms to exert osteogenesis. SHED might be a suitable resource for orofacial bone regeneration. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | stem cells from human exfoliated deciduous teeth (SHED) | en |
dc.subject | osteoblast | en |
dc.subject | regeneration | en |
dc.subject | bone | en |
dc.title | SHED repair critical-size calvarial defects in mice | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1601-0825.2007.01396.x | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.