S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior
- Issue Date
- Biomaterials 2005;26:5153-5157
- The surface of titanium implants is in direct contact with host tissue and plays a critical role in determining biocompatibility. Fibronectin (FN) and vitronectin (VN) are major cell adhesive proteins found in the extracellular matrix (ECM) of various tissues, and in circulating blood. The aim of this study was to evaluate the engineered biomimetic surface of titanium by using recombinant fragment of FN8–10 and VNNTD that contains the binding site for integrins. MC3T3-E1 cells seeded upon the FN8−10-coated titanium showed a marked increase in cell adhesion, proliferation, and differentiation over VNNTD-coated titanium. In addition, we confirmed that the surface properties of titanium prefer for FN8–10 over VNNTD (p<0.05) in protein adhesion. These results suggest that the FN8–10-modified titanium surface can be used to improve the osseointegration of titanium implants by enhancing bone formation.
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