Browse

Synergistic activity of fibronectin and fibroblast growth factor receptors on neuronal adhesion and neurite extension through extracellular signal-regulated kinase pathway

DC Field Value Language
dc.contributor.authorSeo, Byoung-Moo-
dc.contributor.authorChoung, Pill-Hoon-
dc.contributor.authorChung, Chong-Pyoung-
dc.contributor.authorYamada, Kenneth M-
dc.contributor.authorJang, Jun-Hyeog-
dc.date.accessioned2010-09-05T23:47:11Z-
dc.date.available2010-09-05T23:47:11Z-
dc.date.issued2002-07-
dc.identifier.citationBiochemical and Biophysical Research Communications 295 (2002) 898-902en
dc.identifier.issn0006-291X-
dc.identifier.urihttps://hdl.handle.net/10371/69703-
dc.description.abstractFibroblast growth factor (FGF) is an important modulator of cell growth and differentiation of various cells including neuron. Cells need to adhere specifically to cellular and extracellular components of their environment to carry out diverse physiological functions. Here, we examined whether fibronectin (FN) and FGF can cooperate for neuronal adhesion and neurite outgrowth. Using recombinant FN peptide (FNIII9–10), we found that FNIII9–10-mediated adhesion promotes the effect of FGF1 on neurite outgrowth of PC12 cells, while FGF1 enhances the FNIII9–10-mediated neuronal adhesion of PC12 cells. This collaboration of FNIII9–10 and FGF1 was the result of the sustained activation of extracellular signal-regulated kinase (ERK)-type MAP kinase. Finally, the synergistic activity of FGF1 and FN was inhibited by PD98059, an MEK inhibitor. Taken together, these findings indicate that FN-mediated signaling can collaborate with FGFRs signaling for neurite outgrowth through selective activation of ERK-type MAP kinase in PC12 cells, and suggest that FN and FGF act in concert to regulate cell differentiation in the nervous system.en
dc.description.sponsorshipThis work was supported by the Korea Science and Engineering
Foundation through the Intellectual Biointerface Engineering Center
at Seoul National University.
en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectFGFRen
dc.subjectFGFen
dc.subjectFibronectinen
dc.subjectIntegrinen
dc.subjectNeurite outgrowthen
dc.titleSynergistic activity of fibronectin and fibroblast growth factor receptors on neuronal adhesion and neurite extension through extracellular signal-regulated kinase pathwayen
dc.typeArticleen
dc.contributor.AlternativeAuthor서병무-
dc.contributor.AlternativeAuthor정필훈-
dc.contributor.AlternativeAuthor정종평-
dc.contributor.AlternativeAuthor장준혁-
dc.identifier.doi10.1016/S0006-291X(02)00774-X-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse