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Tetraspanin CD9 regulates osteoclastogenesis via regulation of p4442 MAPK activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Gwan-Shik | - |
dc.contributor.author | Yi, TacGhee | - |
dc.contributor.author | Kim, Hye-Jin | - |
dc.contributor.author | Cho, Je-Yoel | - |
dc.contributor.author | Woo, Kyung Mi | - |
dc.contributor.author | Ryoo, Hyun-Mo | - |
dc.contributor.author | Baek, Jeong-Hwa | - |
dc.date.accessioned | 2010-09-06T03:06:48Z | - |
dc.date.available | 2010-09-06T03:06:48Z | - |
dc.date.issued | 2006-08 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications 347 (2006) 178-184 | en |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/69737 | - |
dc.description.abstract | Tetraspanin CD9 has been shown to regulate cell–cell fusion in sperm-egg fusion and myotube formation. However, the role of CD9 in osteoclast, another multinucleated cell type, is not still clear. Therefore, we investigated the role of CD9 in osteoclast differentiation. CD9 was expressed in osteoclast lineage cells and its expression level increased during the progression of RANKL-induced osteoclastogenesis. KMC8, a neutralizing antibody specific to CD9, significantly suppressed RANKL-induced multinucleated osteoclast formation and the mRNA expression of osteoclast differentiation marker genes. To define CD9-regulated osteoclastogenic signaling pathway, MAPK pathways were examined. KMC8 induced long-term phosphorylation of p44/42 MAPK, but not of p38 MAPK. Constitutive activation of p44/42 MAPK by overexpressing constitutive-active mutant of MEK1 almost completely blocked osteoclast differentiation. Taken together, these results suggest that CD9 expressed on osteoclast lineage cells might positively regulate osteoclastogenesis via the regulation of p44/42 MAPK activity. | en |
dc.description.sponsorship | This work was supported by R04-2002-000-00090-0
from Korea Science and Engineering Foundation. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Osteoclastogenesis | en |
dc.subject | Multinuclear osteoclast | en |
dc.subject | CD9 | en |
dc.subject | KMC8 | en |
dc.subject | p44/42 MAPK | en |
dc.title | Tetraspanin CD9 regulates osteoclastogenesis via regulation of p4442 MAPK activity | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김관식 | - |
dc.contributor.AlternativeAuthor | 이택기 | - |
dc.contributor.AlternativeAuthor | 김혜진 | - |
dc.contributor.AlternativeAuthor | 조재열 | - |
dc.contributor.AlternativeAuthor | 우경미 | - |
dc.contributor.AlternativeAuthor | 류현모 | - |
dc.contributor.AlternativeAuthor | 백정화 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.06.061 | - |
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