Publications
Detailed Information
"Immunoregulatory effects of extracts from the stem bark of Albizzia julibrissin Durazz
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Youngnim | - |
dc.contributor.author | Kim, Jeong J | - |
dc.contributor.author | Lee, Byung E | - |
dc.contributor.author | Jung, Dong S | - |
dc.contributor.author | Kim, Se Won | - |
dc.contributor.author | Ko, Seon Yle | - |
dc.contributor.author | Baek, Dong Heon | - |
dc.contributor.author | Chang, Sun Hwa | - |
dc.date.accessioned | 2010-09-09T06:20:45Z | - |
dc.date.available | 2010-09-09T06:20:45Z | - |
dc.date.issued | 2004-12 | - |
dc.identifier.citation | International Journal of Oral Biology 29:137-144 | en |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://hdl.handle.net/10371/69784 | - |
dc.description.abstract | Although there are many disease modifying antirheumatic drugs (DMARDs) available, more safe and effective reagents have yet to be developed. Activated T cells make good targets for DMARD therapy. Therefore, we screened over fifty herbal extracts, and identified that water extract from the stem bark of Albizzia julibrissin selectively killed activated T cells but not naive splenocytes, in vitro. Wb3-3, obtained by further extraction and column chromatography to maximize selective activity, was used for further investigation. Annexin-V and caspase activity assay revealed that WB3-3 killed activated T cells by inducing apoptosis, which was mediated through mainly caspase-8 rather than caspase-9. The effect of WB3-3 in vivo was conlirmed by the elimination of V8- but no V6-T cells following activation with Streptococcal Enterotoxin B (SEB). Furthermore, WB3-3 inhibited neither CD25 upregulationnor proliferative response, and rather increased IL-2 secretion during Con A activation of naive T cells.Our results imply the potential of WB3-3 to include a lead compound for a new immunoregulatory drug. | en |
dc.language.iso | en | en |
dc.publisher | Korean Acadamy of Oral Biology | en |
dc.subject | disease modifying anti-rheumatic(DMARD) | en |
dc.subject | albizzia julibrissin | en |
dc.subject | activated T cell | en |
dc.subject | apoptosis | en |
dc.subject | caspase-8 | en |
dc.title | "Immunoregulatory effects of extracts from the stem bark of Albizzia julibrissin Durazz | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최영님 | - |
dc.contributor.AlternativeAuthor | 김세원 | - |
dc.contributor.AlternativeAuthor | 고선일 | - |
dc.contributor.AlternativeAuthor | 백동헌 | - |
dc.contributor.AlternativeAuthor | 장선화 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.