신의 처리상과 유도성 이뇨상에 미치는 Triiodothyronine의 영향에 관한 실험적 연구

Abstract

An experimental study was attempted to evaluate the effect of triiodothyronine CT,) on handling of lithium and lithium induced diuresis by the kidney of rabbits. Triiodothyronine CO. 5mg/kg) was given to 17 healthy rabbitstl', treated or experimental group), every other day upto 3 injections and LiCI solution OmM/kg) was given to both the T, treated group and 13 healthy rabbitsfcontrol group), intra' peritoneally everyday for 3 days for the pre-experimental preperation. On the day of experiment, urine osmolarity, urine volume, urinary excretion of lithium, potassium, were measured prior to intravenous lithium injection C2mM/kg), and 10 minutes, 30 minutes, 60 minutes after the lithium injection as well as those of serum concentration. The results obtained by analyses of the above mentioned factors were as follows: 1. Urinary lithium excretion of T a treated group was much lesser than that of control group. 2. Serum lithium concentration tended to be decreased in T 3 treated group. 3. Urine volume and urinary sodium excretion of the rabbits given small amount of lithium tended to be increased in T 3 treated group. 4. Immediate water diuresis and natriuresis caused by acute injection of large amount of lithium tended to be lower in T 3 treated group. 5. Lithium clearance inclined to be low In T3 treated group than in control group, but no significant differences were found between the two groups regarding the osmolarity and free water clearance. From the above results, it is suggested that thyroid hormone increases the renal tubular lithium reabsorption without significant change of lithium-induced diuretic effect, and thyroid hormone decreases the plasma lithium concentration due to intracellular influx of plasma lithium in various tissue cells.