S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 24 No.3 (1983)
신의 처리상과 유도성 이뇨상에 미치는 Triiodothyronine의 영향에 관한 실험적 연구
Effect of Triiodothyronine on Handling of Lithium and Lithium-induced Diuresis by Kidney in Rabbits
- 최낙규; 이희영
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.24 No.3, pp. 301-310
- An experimental study was attempted to evaluate
the effect of triiodothyronine CT,) on handling of
lithium and lithium induced diuresis by the kidney
of rabbits. Triiodothyronine CO. 5mg/kg) was given
to 17 healthy rabbitstl', treated or experimental
group), every other day upto 3 injections and LiCI
solution OmM/kg) was given to both the T, treated
group and 13 healthy rabbitsfcontrol group), intra'
peritoneally everyday for 3 days for the pre-experimental
On the day of experiment, urine osmolarity, urine
volume, urinary excretion of lithium, potassium,
were measured prior to intravenous lithium injection
C2mM/kg), and 10 minutes, 30 minutes, 60 minutes
after the lithium injection as well as those of serum
The results obtained by analyses of the above
mentioned factors were as follows:
1. Urinary lithium excretion of T a treated group
was much lesser than that of control group.
2. Serum lithium concentration tended to be decreased
in T 3 treated group. 3. Urine volume and urinary sodium excretion of
the rabbits given small amount of lithium tended to
be increased in T 3 treated group.
4. Immediate water diuresis and natriuresis caused
by acute injection of large amount of lithium tended
to be lower in T 3 treated group.
5. Lithium clearance inclined to be low In T3
treated group than in control group, but no significant
differences were found between the two groups
regarding the osmolarity and free water clearance.
From the above results, it is suggested that thyroid
hormone increases the renal tubular lithium reabsorption
without significant change of lithium-induced
diuretic effect, and thyroid hormone decreases the
plasma lithium concentration due to intracellular
influx of plasma lithium in various tissue cells.