S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 24 No.4 (1983)
Corticosterone이 백서 뇌내 Norepinephrine, Dopamine 및 Serotonin함럄 에 미치는 영향에 관한 실험적 연구
Effect of Corticosterone on the Contents of Norepinephrine, Dopamine and Serotonin in the Rat Brain
- 조수철; 서유헌; 우종인; 박찬웅; 이정균
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.24 No.4, pp. 388-402
- It has been well known that glucocorticoid hormone
can induce mental symptoms, mainly depressive or
manic symptom. And many investigators suggest
that some change in the monoamine contents can
induce affective disorders,
In this study, in order to investigate the effect of
corticosterone on the brain monoamines in rats, the
contents of norepinephrine(NE), dopamine(DA) and
5-hydroxy·tryptamine(5-HT) were determined fluorophotometrically
two and seven days after adrenalectomy
and we also checked the contents of monoamines
before and after administration of corticosterone
to adrenalectomized rats.
The results are summarized as follows.
1) Two and seven days after adrenalectomy, there
were decreases in NE and DA contents and an increase
in 5-HT con ten t.
2) Administration of corticosterone in adrenalectomized
rats caused increases in the concentrations of
NE and DA, hut caused decrease in that of 5-HT.
3) The concentration of monoarnines were more
markedly changed two days after adrenalectomy than
1) Changes in the concentrations of 5-HT were
relatively dose-dependent but those of NE and DA
were not so definite as 5-HT.
In conclusion, it is strongly suggested that corticosterone
may significantly affect the contents of dop·
amine, norepinephrine and S-hydroxytryptamine in
several regions of rat brain and these changes may
playa role in the mechanism of steroid related mental