Corticosterone이 백서 뇌내 Norepinephrine, Dopamine 및 Serotonin함럄 에 미치는 영향에 관한 실험적 연구

Abstract

It has been well known that glucocorticoid hormone can induce mental symptoms, mainly depressive or manic symptom. And many investigators suggest that some change in the monoamine contents can induce affective disorders, In this study, in order to investigate the effect of corticosterone on the brain monoamines in rats, the contents of norepinephrine(NE), dopamine(DA) and 5-hydroxy·tryptamine(5-HT) were determined fluorophotometrically two and seven days after adrenalectomy and we also checked the contents of monoamines before and after administration of corticosterone to adrenalectomized rats. The results are summarized as follows. 1) Two and seven days after adrenalectomy, there were decreases in NE and DA contents and an increase in 5-HT con ten t. 2) Administration of corticosterone in adrenalectomized rats caused increases in the concentrations of NE and DA, hut caused decrease in that of 5-HT. 3) The concentration of monoarnines were more markedly changed two days after adrenalectomy than seven days. 1) Changes in the concentrations of 5-HT were relatively dose-dependent but those of NE and DA were not so definite as 5-HT. In conclusion, it is strongly suggested that corticosterone may significantly affect the contents of dop· amine, norepinephrine and S-hydroxytryptamine in several regions of rat brain and these changes may playa role in the mechanism of steroid related mental symptoms.