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Glomerular Hyalinosis in Relation to Lipid Deposition in Rats with Reduced Renal Mass
신장 절제술을 시행한 쥐에서 관찰되는 지방 침착과 유관한 하이알리노시스에 관한 연구

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dc.contributor.authorLee, Hyun Soon-
dc.date.accessioned2009-08-20T05:13:48Z-
dc.date.available2009-08-20T05:13:48Z-
dc.date.issued1990-06-
dc.identifier.citationSeoul J Med, Vol.31 No.2, pp. 97-106-
dc.identifier.issn0582-6802-
dc.identifier.urihttps://hdl.handle.net/10371/7308-
dc.description.abstractStudies have suggested that similarities exist between the pathogenesis of
glomerulosclerosis and atherosclerosis. The role of subendothelial accumulation of
macromolecular substances, lipids in particular, in the pathogenesis of glomerular hyalinosis
and sclerosis was studied in 17 Sprague-Dawley rats with reduced renal mass (1 and 1/3
nephrectomy). Sequential changes of functional and morphologic data were studied three,
five and seven months after ablation. Urinary protein excretion, and values for blood urea
nitrogen, creatinine, fasting serum cholesterol, and triglycerides all increased by the third
month following operation. After the seven months, the rats had a significantly higher daily
urine protein excretion than animals at month 3 and greater values for fasting serum
cholesterol and triglycerides than animals at month 5. By light microscopy, animals at month
7 showed a significantly greater percentage of glomeruli with segmental hyalinosis/sclerosis
than rats at month 3. Glomerular lipid deposition, confirmed by oil red 0 staining, was noted
in 11 animats (65%). Ultrastructurally, a subendothelial accumulation of fat and electron-
dense proteinaceous material, which corresponded to the early hyalinosis lesion in glomeruli,
was observed more frequently in rats at month 7 than in animals at months 3 and 5.
Mesangial deposition of the same substances was seen in nine rats showing no significant
difference in each group. These observations suggest that the development of glomerular
hyalinosis may be related to the subendothelial deposition of harmful lipids in the circulation,
similar to arterial wall damage in atherosclerosis, eventually leading to glomerular sclerosis.
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dc.language.isoen-
dc.publisherSeoul National University College of Medicine-
dc.subjectRenal ablation-
dc.subjectGlomerular hyalinosis-
dc.subjectIntraglomerolar lipid deposition-
dc.titleGlomerular Hyalinosis in Relation to Lipid Deposition in Rats with Reduced Renal Mass-
dc.title.alternative신장 절제술을 시행한 쥐에서 관찰되는 지방 침착과 유관한 하이알리노시스에 관한 연구-
dc.typeSNU Journal-
dc.contributor.AlternativeAuthor이현순-
dc.citation.journaltitle서울 의대 잡지-
dc.citation.journaltitle서울 의대 학술지-
dc.citation.journaltitleSeoul Journal of Medicine-
dc.citation.endpage106-
dc.citation.number2-
dc.citation.pages97-106-
dc.citation.startpage97-
dc.citation.volume31-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 31 No.2 (1990)
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