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Overexpression of Interleukin-10 in Sentinel Lymph Node with Breast Cancer

Cited 5 time in Web of Science Cited 5 time in Scopus
Authors
Woo, Sang Uk; Bae, Jeoung Won; Yang, Jung-Hyun; Kim, Jung Han; Nam, Seok Jin; Shin, Young Kee
Issue Date
2007-11
Publisher
Springer Verlag
Citation
Ann. Surg. Oncol.; Vol.14(11); pp.3268–3273
Keywords
Breast carcinomaSentinel lymph nodeCytokineInterleukin-10Real-time quantitative polymerase chain reaction
Abstract
Background: In breast carcinoma, identification of tumor cells in the sentinel lymph nodes is a predictor of the tumor’s metastatic potential. Sentinel lymph node may be targeted not only by tumor cell metastasis but also by cytokines from the emergence of antitumor immune responses.
Methods: Between February 2003 and February 2004, the investigator evaluated 38 cases that underwent sentinel lymph node biopsy at the Samsung Medical Center. Eighty paraffin-embedded sections, 49 sentinel, and 31 nonsentinel lymph node, from breast carcinoma without lymphatic metastases were analyzed by real-time polymerase chain reaction to evaluate the cytokine profile (interferon-γ, interleukin-2, interleukin-10 and interleukin-12) for the T cell response.
Results: A higher expression of interleukin-10 was observed in sentinel lymph node than in nonsentinel lymph node (P = 0.03). The expressions of interferon-γ, interleukin-2, and interleukin-12 were similar between sentinel and nonsentinel lymph node.
Conclusions: Theses results indicate that T cell response was downregulated by interleukin-10 overexpression in sentinel lymph node with breast cancer.
ISSN
1068-9265
Language
English
URI
http://hdl.handle.net/10371/73423
DOI
https://doi.org/10.1245/s10434-007-9532-3
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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