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Overexpression of Interleukin-10 in Sentinel Lymph Node with Breast Cancer

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dc.contributor.authorWoo, Sang Uk-
dc.contributor.authorBae, Jeoung Won-
dc.contributor.authorYang, Jung-Hyun-
dc.contributor.authorKim, Jung Han-
dc.contributor.authorNam, Seok Jin-
dc.contributor.authorShin, Young Kee-
dc.date.accessioned2011-06-13T06:19:04Z-
dc.date.available2011-06-13T06:19:04Z-
dc.date.issued2007-11-
dc.identifier.citationAnn. Surg. Oncol.; Vol.14(11); pp.3268–3273en
dc.identifier.issn1068-9265-
dc.identifier.urihttp://hdl.handle.net/10371/73423-
dc.description.abstractBackground: In breast carcinoma, identification of tumor cells in the sentinel lymph nodes is a predictor of the tumor’s metastatic potential. Sentinel lymph node may be targeted not only by tumor cell metastasis but also by cytokines from the emergence of antitumor immune responses.
Methods: Between February 2003 and February 2004, the investigator evaluated 38 cases that underwent sentinel lymph node biopsy at the Samsung Medical Center. Eighty paraffin-embedded sections, 49 sentinel, and 31 nonsentinel lymph node, from breast carcinoma without lymphatic metastases were analyzed by real-time polymerase chain reaction to evaluate the cytokine profile (interferon-γ, interleukin-2, interleukin-10 and interleukin-12) for the T cell response.
Results: A higher expression of interleukin-10 was observed in sentinel lymph node than in nonsentinel lymph node (P = 0.03). The expressions of interferon-γ, interleukin-2, and interleukin-12 were similar between sentinel and nonsentinel lymph node.
Conclusions: Theses results indicate that T cell response was downregulated by interleukin-10 overexpression in sentinel lymph node with breast cancer.
en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectBreast carcinomaen
dc.subjectSentinel lymph nodeen
dc.subjectCytokineen
dc.subjectInterleukin-10en
dc.subjectReal-time quantitative polymerase chain reactionen
dc.titleOverexpression of Interleukin-10 in Sentinel Lymph Node with Breast Canceren
dc.typeArticleen
dc.contributor.AlternativeAuthor우상욱-
dc.contributor.AlternativeAuthor배정원-
dc.contributor.AlternativeAuthor양정현-
dc.contributor.AlternativeAuthor김정한-
dc.contributor.AlternativeAuthor남석진-
dc.contributor.AlternativeAuthor신영기-
dc.identifier.doi10.1245/s10434-007-9532-3-
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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