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Overexpression of Interleukin-10 in Sentinel Lymph Node with Breast Cancer
Cited 6 time in
Web of Science
Cited 6 time in Scopus
- Authors
- Issue Date
- 2007-11
- Publisher
- Springer Verlag
- Citation
- Ann. Surg. Oncol.; Vol.14(11); pp.3268–3273
- Keywords
- Breast carcinoma ; Sentinel lymph node ; Cytokine ; Interleukin-10 ; Real-time quantitative polymerase chain reaction
- Abstract
- Background: In breast carcinoma, identification of tumor cells in the sentinel lymph nodes is a predictor of the tumors metastatic potential. Sentinel lymph node may be targeted not only by tumor cell metastasis but also by cytokines from the emergence of antitumor immune responses.
Methods: Between February 2003 and February 2004, the investigator evaluated 38 cases that underwent sentinel lymph node biopsy at the Samsung Medical Center. Eighty paraffin-embedded sections, 49 sentinel, and 31 nonsentinel lymph node, from breast carcinoma without lymphatic metastases were analyzed by real-time polymerase chain reaction to evaluate the cytokine profile (interferon-γ, interleukin-2, interleukin-10 and interleukin-12) for the T cell response.
Results: A higher expression of interleukin-10 was observed in sentinel lymph node than in nonsentinel lymph node (P = 0.03). The expressions of interferon-γ, interleukin-2, and interleukin-12 were similar between sentinel and nonsentinel lymph node.
Conclusions: Theses results indicate that T cell response was downregulated by interleukin-10 overexpression in sentinel lymph node with breast cancer.
- ISSN
- 1068-9265
- Language
- English
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