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Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins
DC Field | Value | Language |
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dc.contributor.author | Han, Seungnam | - |
dc.contributor.author | Nam, Jungyong | - |
dc.contributor.author | Li, Yan | - |
dc.contributor.author | Kim, Seho | - |
dc.contributor.author | Cho, Suk-Hee | - |
dc.contributor.author | Cho, Yi Sul | - |
dc.contributor.author | Choi, So-Yeon | - |
dc.contributor.author | Choi, Jeonghoon | - |
dc.contributor.author | Han, Kihoon | - |
dc.contributor.author | Kim, Youngrim | - |
dc.contributor.author | Na, Moonseok | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Bae, Yong Chul | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Kim, Eunjoon | - |
dc.date.accessioned | 2011-10-13T05:19:27Z | - |
dc.date.available | 2011-10-13T05:19:27Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | Journal of Neuroscience 30:15102-15112 | en |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74098 | - |
dc.description.abstract | PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the
underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. Overexpression of TANC1 and TANC2 in cultured neurons increases the density of dendritic spines and excitatory synapses in a manner that requires thePDZ(PSD-95/Dlg/ZO-1)-binding C termini of TANC proteins. TANC1-deficient mice exhibit reduced spine density in the CA3 region of the hippocampus, but not in the CA1 or dentate gyrus regions, and show impaired spatial memory. TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development. | en |
dc.description.sponsorship | This work was supported by the Korea Science Foundation grant (to S.Y.C.; 313-2007-2-C00630), the Basic Science Research Program (to Y.C.B.; R13-2008-009-01001-0), and the National Creative Research Initiative Program
(to E.K.) from the Korean Ministry of Education, Science, and Technology. | en |
dc.language.iso | en | en |
dc.publisher | Society for Neuroscience | en |
dc.title | Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 한승남 | - |
dc.contributor.AlternativeAuthor | 남정용 | - |
dc.contributor.AlternativeAuthor | 김세호 | - |
dc.contributor.AlternativeAuthor | 조석희 | - |
dc.contributor.AlternativeAuthor | 최소연 | - |
dc.contributor.AlternativeAuthor | 최정훈 | - |
dc.contributor.AlternativeAuthor | 한기훈 | - |
dc.contributor.AlternativeAuthor | 김영림 | - |
dc.contributor.AlternativeAuthor | 나문석 | - |
dc.contributor.AlternativeAuthor | 김현 | - |
dc.contributor.AlternativeAuthor | 배용철 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.contributor.AlternativeAuthor | 김은준 | - |
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