Publications
Detailed Information
Microglial toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Jinpyo | - |
dc.contributor.author | Cho, Ik-Hyun | - |
dc.contributor.author | Kwak, Kyung Il | - |
dc.contributor.author | Suh, Eun Cheng | - |
dc.contributor.author | Seo, Jinsoo | - |
dc.contributor.author | Min, Hyun Jung | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Kim, Chong-Hyun | - |
dc.contributor.author | Park, Seung Hwa | - |
dc.contributor.author | Jo, Eun-Kyeong | - |
dc.contributor.author | Lee, Soojin | - |
dc.contributor.author | Lee, Kyung Eun | - |
dc.contributor.author | Lee, Sung Joong | - |
dc.date.accessioned | 2011-10-13T05:55:13Z | - |
dc.date.available | 2011-10-13T05:55:13Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | Journal of Biological Chemistry 285,39447-39457 | en |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74102 | - |
dc.description.abstract | Recent studies indicate that Toll-like receptors (TLRs), originally identified as infectious agent receptors, also mediate sterile inflammatory responses during tissue damage. In this study, we investigated the role of TLR2 in excitotoxic hippocampal cell death using TLR2 knock-out (KO) mice. TLR2 expression was up-regulated in microglia in the ipsilateral hippocampus of kainic acid (KA)-injected mice. KA-mediated hippocampal cell death was significantly reduced in TLR2 KO mice compared with wild-type (WT) mice. Similarly, KA-induced glial activation and proinflammatory gene expression in the hippocampus were compromised in TLR2 KO mice. In addition, neurons in organotypic hippocampal slice cultures (OHSCs) from TLR2 KO mouse brains were less susceptible to KA excitotoxicity than WT OHSCs. This protection is partly attributed to decreased expression of proinflammatory genes, such as TNF-α and IL-1β in TLR2 KO mice OHSCs. These data demonstrate conclusively that TLR2 signaling in microglia contributes to KA-mediated innate immune responses and hippocampal excitotoxicity. | en |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology(MEST) (No.2009-0081467,2009-0063285,2009-0053167), the Republic of Korea, and the Korea Science and Engineering Foundation through the Infection Signaling Network Research Center (R13-2007-020-01000-0) at Chungnam National University. | en |
dc.language.iso | en | en |
dc.publisher | American Society for Biochemistry and Molecular Biology | en |
dc.title | Microglial toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 홍진표 | - |
dc.contributor.AlternativeAuthor | 조익현 | - |
dc.contributor.AlternativeAuthor | 곽경일 | - |
dc.contributor.AlternativeAuthor | 서은정 | - |
dc.contributor.AlternativeAuthor | 서진수 | - |
dc.contributor.AlternativeAuthor | 민현정 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.contributor.AlternativeAuthor | 김종현 | - |
dc.contributor.AlternativeAuthor | 박승화 | - |
dc.contributor.AlternativeAuthor | 조은경 | - |
dc.contributor.AlternativeAuthor | 이수진 | - |
dc.contributor.AlternativeAuthor | 이경은 | - |
dc.contributor.AlternativeAuthor | 이성중 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.