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Electrospun silk fibroin scaffolds with macropores for bone regeneration: An in vitro and in vivo study
DC Field | Value | Language |
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dc.contributor.author | Park, Sook Young | - |
dc.contributor.author | Ki, Chang Seok | - |
dc.contributor.author | Park, Young Hwan | - |
dc.contributor.author | Jung, Hong Moon | - |
dc.contributor.author | Woo, Kyung Mi | - |
dc.contributor.author | Kim, Hyun Jeong | - |
dc.date.accessioned | 2011-10-14T08:21:54Z | - |
dc.date.available | 2011-10-14T08:21:54Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.citation | Tissue Engineering - Part A 16:4,1271-1279 | en |
dc.identifier.issn | 1937-3341 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74174 | - |
dc.description.abstract | We developed three-dimensional electrospun silk fibroin (ESF) scaffolds with controllable pore size. The purpose of this study was to evaluate ESF scaffolds with pores (P-ESF) for bone regeneration via in vitro and in vivo studies, with a comparison to a commercially available porous three-dimensional polylactic acid (PLA) scaffold. P-ESF supported significantly higher proliferation and alkaline phosphatase activity of osteoblasts than PLA in vitro (p<0.05). Moreover, higher expression levels of activated adhesion-related proteins, including focal adhesion kinase, were observed in the P-ESF than in PLA, as confirmed by western blot analyses. Microcomputed tomography revealed that 78.30% of the original bone volume was attained in the P-ESF implantation group at 7 weeks after critical bone defect formation in rat calvaria. Comparatively, the PLA implantation group showed only 49.31%. Histological evaluation also showed new bone tissue formation upon P-ESF implantation. Taken together, the P-ESF scaffold may be a good bone substitute for bone regeneration. | en |
dc.description.sponsorship | The authors thank the Korea Science and Engineering Foundation (KOSEF) and Rural Development Administration, Republic of Korea, for sponsoring this research through
the SRC=ERC Program of MOST=KOSEF (R11-2005-065), and BioGreen21 Program (200810FTH010102001). | en |
dc.language.iso | en | en |
dc.publisher | Mary Ann Liebert | en |
dc.title | Electrospun silk fibroin scaffolds with macropores for bone regeneration: An in vitro and in vivo study | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박숙영 | - |
dc.contributor.AlternativeAuthor | 기창석 | - |
dc.contributor.AlternativeAuthor | 박영환 | - |
dc.contributor.AlternativeAuthor | 정홍문 | - |
dc.contributor.AlternativeAuthor | 우경미 | - |
dc.contributor.AlternativeAuthor | 김현정 | - |
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