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DGKi regulates presynaptic release during mGluR-dependent LTD
DC Field | Value | Language |
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dc.contributor.author | Yang, Jinhee | - |
dc.contributor.author | Seo, Jinsoo | - |
dc.contributor.author | Nair, Ramya | - |
dc.contributor.author | Han, Seungnam | - |
dc.contributor.author | Jang, Seil | - |
dc.contributor.author | Kim, Karam | - |
dc.contributor.author | Han, Kihoon | - |
dc.contributor.author | Paik, Sang Kyoo | - |
dc.contributor.author | Choi, Jeonghoon | - |
dc.contributor.author | Lee, Seunghoon | - |
dc.contributor.author | Bae, Yong Chul | - |
dc.contributor.author | Topham, Matthew K | - |
dc.contributor.author | Prescott, Stephen M | - |
dc.contributor.author | Rhee, Jeong-Seop | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Kim, Eunjoon | - |
dc.date.accessioned | 2011-10-17T01:38:33Z | - |
dc.date.available | 2011-10-17T01:38:33Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.citation | The EMBO Journal 30:165-180 | en |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74187 | - |
dc.description.abstract | Diacylglycerol (DAG) is an important lipid second messenger. DAG signalling is terminated by conversion of DAG to phosphatidic acid (PA) by diacylglycerol kinases (DGKs). The neuronal synapse is a major site of DAG production and action; however, how DGKs are targeted to subcellular sites of DAG generation is largely unknown. We report here that postsynaptic density (PSD)-95 family proteins interact with and promote synaptic localization of DGKl. In addition, we establish that DGKl acts presynaptically, a function that contrasts with the known postsynaptic function of DGKl, a close relative of DGKl. Deficiency of DGKl in mice does not affect dendritic spines, but leads to a small increase in presynaptic release probability. In addition, DGKl-/- synapses show a reduction in metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) at neonatal (∼2 weeks) stages that involve suppression of a decrease in presynaptic release probability. Inhibition of protein kinase C normalizes presynaptic release probability and mGluR-LTD at DGKl-/- synapses. These results suggest that DGKl requires PSD-95 family proteins for synaptic localization and regulates presynaptic DAG signalling and neurotransmitter release during mGluR-LTD. | en |
dc.description.sponsorship | This work was supported by the NIH R01-CA95463 grant (to MKT), the Neuroscience Program (to S-YC; 2009-0081468), and the
National Creative Research Initiative Program of the Korean Ministry of Education, Science, and Technology (to EK). | en |
dc.language.iso | en | en |
dc.publisher | Nature Publishing Group | en |
dc.subject | diacylglycerol kinase | en |
dc.subject | long-term depression | en |
dc.subject | metabotropic glutamate receptors | en |
dc.subject | phospholipase C | en |
dc.subject | PSD-95 | en |
dc.title | DGKi regulates presynaptic release during mGluR-dependent LTD | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 양진희 | - |
dc.contributor.AlternativeAuthor | 서진수 | - |
dc.contributor.AlternativeAuthor | 한승남 | - |
dc.contributor.AlternativeAuthor | 장세일 | - |
dc.contributor.AlternativeAuthor | 김가람 | - |
dc.contributor.AlternativeAuthor | 한기훈 | - |
dc.contributor.AlternativeAuthor | 백상규 | - |
dc.contributor.AlternativeAuthor | 최정훈 | - |
dc.contributor.AlternativeAuthor | 이승훈 | - |
dc.contributor.AlternativeAuthor | 배용철 | - |
dc.contributor.AlternativeAuthor | 이정섭 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.contributor.AlternativeAuthor | 김은준 | - |
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