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Preradiation chemotherapy with ACNU-CDDP in patients with newly diagnosed glioblastoma: A retrospective analysis
DC Field | Value | Language |
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dc.contributor.author | Han, Jung Ho | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Kim, Chae-Yong | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Kim, Il Han | - |
dc.contributor.author | Jung, Hee-Won | - |
dc.date.accessioned | 2011-10-17T04:41:24Z | - |
dc.date.available | 2011-10-17T04:41:24Z | - |
dc.date.created | 2020-02-19 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.citation | Chemotherapy, Vol.55 No.3, pp.145-154 | - |
dc.identifier.issn | 0009-3157 | - |
dc.identifier.other | 91860 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74203 | - |
dc.description.abstract | Objective: We evaluated the benefit of preradiation chemotherapy with ACNU (nimustine) and CDDP ( cisplatin) in patients with newly diagnosed glioblastoma by retrospective analysis. Methods: A total of 151 patients were newly confirmed to have glioblastoma between January 2000 and December 2004. All patients underwent surgical resection: 38 (25.2%) patients underwent complete resection, 73 (48.3%) underwent incomplete resection and 40 (26.5%) underwent biopsy. Preradiation chemotherapy using ACNU-CDDP was administered as an initial adjuvant therapy for 87 (57.6%) patients (ACNU-CDDP group), radiation therapy was performed in 31 ( 20.5%) patients (RT group) and the remaining 33 (21.9%) patients were treated with other regimens or refused to undergo further treatment. Results: The median survival time was 13 months (95% CI 11.29-14.71), and the overall survival rate was 54.0% at 1 year and 21.3% at 2 years. The differences in median survival time between the complete resection group and biopsy group and between the ACNU-CDDP group and RT group were significant (15.0 vs. 10 months, p = 0.028, and 16.0 vs. 12.0 months, p = 0.036, respectively) in the univariate analyses. Even in the multivariate analysis, preradiation chemotherapy using ACNU-CDDP had a significant effect on survival prolongation (HR = 0.628, p = 0.042). The usage of temozolomide for adjuvant or salvage therapy also had an independent and significantly positive effect on survival ( HR = 0.511, p = 0.006). Grade 3 and 4 hematologic toxicities occurred in 28 (32.1%) patients in the ACNU-CDDP group, but there were no treatment-related deaths. Conclusion: Preradiation chemotherapy with ACNU-CDDP as an initial therapy for patients with newly diagnosed glioblastoma is feasible and should be assessed in a randomized phase III study. Copyright (C) 2009 S. Karger AG, Basel | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | S. Karger AG | - |
dc.title | Preradiation chemotherapy with ACNU-CDDP in patients with newly diagnosed glioblastoma: A retrospective analysis | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 정희원 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 한정호 | - |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 김재용 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.contributor.AlternativeAuthor | 김일한 | - |
dc.identifier.doi | 10.1159/000214142 | - |
dc.citation.journaltitle | Chemotherapy | - |
dc.identifier.wosid | 000265863400002 | - |
dc.identifier.scopusid | 2-s2.0-65449137981 | - |
dc.citation.endpage | 154 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 145 | - |
dc.citation.volume | 55 | - |
dc.identifier.sci | 000265863400002 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Han, Jung Ho | - |
dc.contributor.affiliatedAuthor | Park, Chul-Kee | - |
dc.contributor.affiliatedAuthor | Kim, Chae-Yong | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Paek, Sun Ha | - |
dc.contributor.affiliatedAuthor | Kim, Dong Gyu | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Kim, Il Han | - |
dc.contributor.affiliatedAuthor | Jung, Hee-Won | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | LONG-TERM SURVIVAL | - |
dc.subject.keywordPlus | COOPERATIVE-ONCOLOGY-GROUP | - |
dc.subject.keywordPlus | HIGH-GRADE GLIOMA | - |
dc.subject.keywordPlus | PHASE-II | - |
dc.subject.keywordPlus | MALIGNANT GLIOMAS | - |
dc.subject.keywordPlus | CRANIAL IRRADIATION | - |
dc.subject.keywordPlus | SALVAGE THERAPY | - |
dc.subject.keywordPlus | BRAIN-TUMORS | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | MULTIFORME | - |
dc.subject.keywordAuthor | Glioblastoma | - |
dc.subject.keywordAuthor | Preradiation chemotherapy | - |
dc.subject.keywordAuthor | ACNU | - |
dc.subject.keywordAuthor | Cisplatin | - |
dc.subject.keywordAuthor | Survival | - |
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