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Sox2 expression in brain tumors: a reflection of the neuroglial differentiation pathway

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dc.contributor.authorPhi, Ji Hoon-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorKim, Seung-Ki-
dc.contributor.authorPaek, Sun Ha-
dc.contributor.authorKim, Jin Hyun-
dc.contributor.authorLee, Yun Jin-
dc.contributor.authorCho, Byung-Kyu-
dc.contributor.authorPark, Chul-Kee-
dc.contributor.authorLee, Do-Hun-
dc.contributor.authorWang, Kyu-Chang-
dc.date.accessioned2011-10-17T05:08:11Z-
dc.date.available2011-10-17T05:08:11Z-
dc.date.issued2008-01-
dc.identifier.citationAm J Surg Pathol 2008;32:103–112en
dc.identifier.issn0147-5185-
dc.identifier.urihttps://hdl.handle.net/10371/74207-
dc.description.abstractSox2 is a key transcription factor that maintains the
proliferation of neuroglial stem cells and inhibits neuronal fate
commitment. Moreover, it was recently found that brain tumors
contain stem cells that resemble normal neuroglial stem cells in
many respects. This study was undertaken to describe Sox2
expression in various brain tumors, and to determine whether
Sox2 expression is a universal feature of brain tumors, or whether
its expression is limited to a specific lineage of brain tumors. Sox2
immunohistochemistry was performed on 194 brain tumor tissues
of various kinds. Fetal and adult normal brain tissues obtained by
autopsy and brain tissues of epilepsy patients with cortical dysplasia
were used as controls. Semiquantitative reverse transcription
polymerase chain reaction was used to confirm the immunohistochemical
results. Double immunofluorescence was performed to
characterize the lineage of Sox2-positive cells. Sox2 was found to be
expressed in various glial tumors, including those with astroglial,
oligodendroglial, and ependymal lineages, and in the glial
components of mixed neuroglial tumors, regardless of pathologic
grade. In brain tumors of embryonal origin, supratentorial
primitive neuroectodermal tumors showed robust Sox2 expression,
whereas medulloblastomas and pineoblastomas did not. The
majority of Sox2-positive tumor cells coexpressed glial fibrillary
acidic protein, and most Sox2-negative cells in medulloblastomas
and pineoblastomas showed neuronal differentiation. This study
suggest that Sox2 may be a tumor marker of glial lineages rather
than a universal brain tumor stem cell marker, because its
expression pattern was found to correspond to differentiation
pathways. On the other hand, the aberrant coexpressions of Sox2
and of a neuronal marker were widely observed in glioblastomas,
which reflects a disorganized differentiation pattern that characterizes
highly malignant tumors.
en
dc.description.sponsorshipSupported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (0405-DB01-0104-0006).en
dc.language.isoenen
dc.publisherLippincott, Williams & Wilkinsen
dc.subjectSox2en
dc.subjectneuroepithelial tumoren
dc.subjectglial differentiationen
dc.subjectneuronal differentiationen
dc.subjectbrain tumor stem cellen
dc.titleSox2 expression in brain tumors: a reflection of the neuroglial differentiation pathwayen
dc.typeArticleen
dc.contributor.AlternativeAuthor피지훈-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor김승기-
dc.contributor.AlternativeAuthor백선하-
dc.contributor.AlternativeAuthor김진현-
dc.contributor.AlternativeAuthor이윤진-
dc.contributor.AlternativeAuthor조병규-
dc.contributor.AlternativeAuthor박철기-
dc.contributor.AlternativeAuthor이도훈-
dc.contributor.AlternativeAuthor왕규창-
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