S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation
- Kwon, Byoung S.; Tan, Kong B.; Ni, Jian; Oh, Kwi-Ok; Lee, Zang H; Kim, Kack K.; Kim, Young-J; Wang, Sa; Gentz, Reiner; Yu, Guo-Liang; Harrop, Jeremy; Lyn, Sally D.; Silverman, Carol; Porter, Terence G.; Truneh, Alem; Young, Peter R.
- Issue Date
- J. Bio. Chem. 272,14272-14276
- The tumor necrosis factor receptor (TNFR) superfamily
consists of approximately 10 characterized members
of human proteins. We have identified a new member of
the TNFR superfamily, TR2, from a search of an expressed
sequence tag data base. cDNA cloning and
Northern blot hybridization demonstrated multiple
mRNA species, of which a 1.7-kilobase form was most
abundant. However, TR2 is encoded by a single gene
which, maps to chromosome 1p36.22–36.3, in the same
region as several other members of the TNFR superfamily.
The most abundant TR2 open reading frame encodes
a 283-amino acid single transmembrane protein with a
36-residue signal sequence, two perfect and two imperfect
TNFR-like cysteine-rich domains, and a short cytoplasmic
tail with some similarity to 4–1BB and CD40.
TR2 mRNA is expressed in multiple human tissues and
cell lines and shows a constitutive and relatively high
expression in peripheral blood T cells, B cells, and
monocytes. A TR2-Fc fusion protein inhibited a mixed
lymphocyte reaction-mediated proliferation suggesting
that the receptor and/or its ligand play a role in T cell
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