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Finite-difference Time-domain Study on Birefringence Changes of the Axon During Neural Activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jonghwan | - |
dc.contributor.author | Kim, Sung June | - |
dc.date.accessioned | 2009-08-21T03:21:03Z | - |
dc.date.available | 2009-08-21T03:21:03Z | - |
dc.date.issued | 2009-06 | - |
dc.identifier.citation | J. Opt. Soc. Korea 13, 272-278 (2009) | en |
dc.identifier.issn | 1226-4776 | - |
dc.identifier.uri | https://hdl.handle.net/10371/7430 | - |
dc.description.abstract | Recently, there has been a growing interest in optical imaging of neural activity because the
optical neuroimaging has considerable advantages over conventional imaging. Birefringence of the axon has been reported to change during neural activation, but the neurophysiological origin of the change is still unresolved. This study hypothesizes that the birefringence signal is at least partially attributed to the transient cellular volume change associated with nerve excitation. To examine this hypothesis, we investigated how the intensity of cross-polarized light transmitting through the axon would change as the size of the axon changes. For this purpose, a two-dimensional finitedifference time-domain program was developed with the improvement of the total-field/scatteredfield method which reduces numerical noise. The results support our hypothesis in that the computed cross-polarized signals exhibit some agreement with previously-reported birefringence signals. | en |
dc.description.sponsorship | This work was supported by the ERC program of
MEST/KOSEF (grant #R11-2000-075-01001-0), and the grant from the Industrial technology development program (10031270) of the Ministry of Knowledge Economy (MKE) of Korea. | en |
dc.language.iso | en | en |
dc.publisher | 한국광학회 = Optical Society of Korea | en |
dc.subject | Neural activity | en |
dc.subject | Birefringence signal | en |
dc.subject | Neurophysiological origin | en |
dc.subject | Finite-difference timedomain | en |
dc.title | Finite-difference Time-domain Study on Birefringence Changes of the Axon During Neural Activation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이종환 | - |
dc.contributor.AlternativeAuthor | 김성준 | - |
dc.identifier.doi | 10.3807/JOSK.2009.13.2.272 | - |
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