S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Pre-emptive Effect of Methylprednisolone on the Mechanical Allodynia Development after Peripheral Nerve Injuries in Rats
- Lee, Min Young; Yoon, Tae Gyoon; Sung, Jung-Joon; Kim, Hyun Jeong; Yum, Kwang Won
- Issue Date
- Kor J Anesth 2004;46:S17-S21
- Background: Glucocorticoids have anti-inflammatory effects and have been used to treat many types of nerve injury- associated
chronic pain conditions. A randomized double-blind study was performed to determine if methylprednisolone could prevent the
development of neuropathic pain after a peripheral nerve injury in rats.
Methods: Two groups of rats, one group (n = 50) injected intraperitoneally with methylprednisolone (100 mg/kg/day, for 7
days starting from 3 days prior to the nerve injury) and the other (n = 58) treated with saline with same manner, were compared
in tenns of the incidence and intensity of allodynia after a superior caudal trunk transection at the level between the 3trd and 4th
sacral spinal nerves. The tail-flick responses to normally innocuous mechanical and thermal stimuli applied to the tail were observed
as the behavioral signs of neuropathic pain.
Results: The proportions of rats exhibiting tail-flick responses to the mechanical (but not thermal) stimuli 7, 14 and 21 days
after the nerve injury were significantly smaller in the methylprednisolone-treated group (2, 3 and 4 of 50 rats, respectively) than
in the saline-treated, control group (11, 14 and 15 of 58 rats, respectively) (P = 0.009). However, the pain intensity was similar
in mechanical allodynia developed rats of the two groups (P > 0.05), which was estimated based on the frequency and latency
of the tail-flick responses after applying mechanical and thermal stimuli, respectively.
Conclusions: These results suggest that a pre-emptive treatment with high methylprednisolone doses may be used to prevent
the development of mechanical allodynia following peripheral nerve injuries.