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Activity-Dependent Neuronal Cell Migration Induced by Electrical Stimulation

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dc.contributor.authorJeong, Se Hoon-
dc.contributor.authorJun, Sang Beom-
dc.contributor.authorSong, Jong Keun-
dc.contributor.authorKim, Sung June-
dc.date.accessioned2009-08-21T03:33:17Z-
dc.date.available2009-08-21T03:33:17Z-
dc.date.issued2009-01-
dc.identifier.citationMed Biol Eng Comput 47:93-99en
dc.identifier.issn0140-0118 (print)-
dc.identifier.issn1741-0444 (online)-
dc.identifier.urihttps://hdl.handle.net/10371/7434-
dc.description.abstractRecently, we found that electrical stimulation
can induce neuronal migration in neural networks cultured
for more than 3 weeks on microelectrode arrays. Immunocytochemistry
data showed that the aggregation of neurons
was related to the emergence of astrocytes in culture. In this
study, when neurons were cocultured with astrocytes, electrical
stimulation could induce the migration of neuronal cell
bodies after only 1 week in culture, while the same stimulation
paradigm caused neural necrosis in neuron-only
cultures. In addition, the stimulation-induced migration was
inhibited by blocking action potentials in neural networks
using the voltage-gated sodium channel blocker, tetrodotoxin.
Immunocytochemistry was performed to monitor
precisely the neuronal migration and count the number of
neurons. These results indicate that neuronal migration of
cell bodies is dependent on neuronal activity evoked by
electrical stimulation and can be enhanced by coculturing with astrocytes. We believe this method can be employed as
a means for modifying neural networks and improving the
interface between electrodes and neurons.
en
dc.description.sponsorshipThis work was supported by the Korea Science
and Engineering Foundation (KOSEF) through the Nano Bioelectronics
and Systems Research Center [Grant No. R11-2000-075-
00002-0 for domestic research and R11- 330 2000-075-01001-0 for
international collaboration (June)].
en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectElectrical stimulationen
dc.subjectNeuronal migrationen
dc.subjectMicroelectrode arrayen
dc.subjectAstrocyteen
dc.subjectNeuronal activityen
dc.titleActivity-Dependent Neuronal Cell Migration Induced by Electrical Stimulationen
dc.typeArticleen
dc.contributor.AlternativeAuthor정세훈-
dc.contributor.AlternativeAuthor전상범-
dc.contributor.AlternativeAuthor송종근-
dc.contributor.AlternativeAuthor김성준-
dc.identifier.doi10.1007/s11517-008-0426-8-
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Journal Papers (저널논문_전기·정보공학부)
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