Browse

Biomimetic Nanofibrous Scaffolds: Preparation and Characterization of PGA/Chitin Blend Nanofibers

DC Field Value Language
dc.contributor.authorPark, Ko Eun-
dc.contributor.authorKang, Hyun Ki-
dc.contributor.authorLee, Seung Jin-
dc.contributor.authorMin, Byung-Moo-
dc.contributor.authorPark, Won Ho-
dc.date.accessioned2011-10-20-
dc.date.available2011-10-20-
dc.date.issued2006-01-
dc.identifier.citationBiomacromolecules 2006;7,635–643en
dc.identifier.issn1526-4602-
dc.identifier.urihttps://hdl.handle.net/10371/74356-
dc.description.abstractElectrospinning of poly(glycolic acid) (PGA)/chitin blend solutions in 1,1,1,3,3,3-hexafluoro-2-propanol was investigated to fabricate biodegradable and biomimetic nanostructured scaffolds for tissue engineering. The morphology of the electrospun PGA/chitin blend nanofibers was investigated with a field emission scanning electron microscope. The PGA/chitin blend fibers have average diameters of around 140 nm, and their diameters have a distribution in the range 50−350 nm. The miscibility of PGA/chitin blend fibers was examined by differential scanning calorimetry. The PGA and chitin were immiscible in the as-spun nanofibrous structure. An in vitro degradation study of PGA/chitin blend nanofibers was conducted in phosphate-buffered saline, pH 7.2. It was found that the hydrolytic cleavage of PGA in the blend nanofibers was accelerated by the coexistence of hydrophilic chitin. To assay the cytocompatibility and cell behavior on the PGA/chitin blend nanofibrous scaffolds, cell attachment and spreading of normal human epidermal fibroblasts seeded on the scaffolds were studied. Our results indicate that the PGA/chitin blend nanofibrous matrix, particularly the one that contained 25% PGA and 75% chitin with bovine serum albumin coating, could be a good candidate for tissue engineering scaffolds, because it has an excellent cell attachment and spreading for normal human fibroblasts.en
dc.description.sponsorshipThis work was supported by the Ministry of Commerce, Industry and Energy (Korea).en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.titleBiomimetic Nanofibrous Scaffolds: Preparation and Characterization of PGA/Chitin Blend Nanofibersen
dc.typeArticleen
dc.contributor.AlternativeAuthor박고은-
dc.contributor.AlternativeAuthor강현기-
dc.contributor.AlternativeAuthor이승진-
dc.contributor.AlternativeAuthor민병무-
dc.contributor.AlternativeAuthor박원호-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse