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Biomimetic nanofibrous scaffolds: Preparation and characterization of chitin/silk fibroin blend nanofibers

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dc.contributor.authorPark, Ko Eun-
dc.contributor.authorJung, Sung Youn-
dc.contributor.authorLee, Seung Jin-
dc.contributor.authorMin, Byung-Moo-
dc.contributor.authorPark, Won Ho-
dc.date.accessioned2011-10-20-
dc.date.available2011-10-20-
dc.date.issued2006-05-
dc.identifier.citationInt. J. Biol. Macromol., 38(2006)165en
dc.identifier.issn0141-8130-
dc.identifier.urihttps://hdl.handle.net/10371/74359-
dc.description.abstractElectrospinning of chitin/silk fibroin (SF) blend solutions in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was investigated to fabricate a biomimetic nanostructured scaffolds for tissue engineering. The morphology of the electrospun chitin/SF blend nanofibers was investigated with a field emission scanning electron microscope (FE-SEM). The average diameters of chitin/SF blend fibers decreased from 920 to 340 nm, with the increase of chitin content in blend compositions. The miscibility of chitin/SF blend fibers was examined by solution viscosity measurement. The chitin and SF were immiscible in the as-spun nanofibrous structure. The dimensional stability of chitin/SF blend nanofibers, with or without water vapor after-treatment, was conducted by immersing in water. As-spun SF-rich blend nanofibrous matrices were lost their fibrous structure after the water immersion for 24 h, and then changed into membrane-like structure. On the contrary, nanofibrous structures of water vapor-treated SF-rich blends were almost maintained. To assay the cytocompatibility and cell behavior on the chitin/SF blend nanofibrous scaffolds, cell attachment and spreading of normal human epidermal keratinocyte and fibroblasts seeded on the scaffolds were studied. Our results indicate that chitin/SF blend nanofibrous matrix, particularly the one that contained 75% chitin and 25% SF, could be a potential candidate for tissue engineering scaffolds because it has both biomimetic three-dimensional structure and an excellent cell attachment and spreading for NHEK and NHEF.en
dc.description.sponsorshipThis work was supported by a grant from the Korean Ministry of Commerce, Industry, and Energy and by a grant from the Korean Science and Engineering Foundation through the Intellectual Biointerface Engineering Center at Seoul National University.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectElectrospinningen
dc.subjectChitinen
dc.subjectSilk fibroinen
dc.subjectBlend nanofiberen
dc.subjectMatrixen
dc.subjectFibroblasten
dc.titleBiomimetic nanofibrous scaffolds: Preparation and characterization of chitin/silk fibroin blend nanofibersen
dc.typeArticleen
dc.contributor.AlternativeAuthor박고은-
dc.contributor.AlternativeAuthor정성윤-
dc.contributor.AlternativeAuthor이승진-
dc.contributor.AlternativeAuthor민병무-
dc.contributor.AlternativeAuthor박원호-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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