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Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | La, Jun-Ho | - |
dc.contributor.author | Sung, Tae-Sik | - |
dc.contributor.author | Kim, Hyun-Ju | - |
dc.contributor.author | Kim, Tae-Wan | - |
dc.contributor.author | Kang, Tong Mook | - |
dc.contributor.author | Yang, Il Suk | - |
dc.date.accessioned | 2009-08-21T08:20:02Z | - |
dc.date.available | 2009-08-21T08:20:02Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | World J Gastroenterol 2008; 14: 731-736 | en |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://hdl.handle.net/10371/7470 | - |
dc.description.abstract | AIM: To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis.
METHODS: We measured mucosal myeloperoxidase (MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid. RESULTS: Colonic inflammation, quantified by MPO activity, significantly increased on d 2 and subsided thereafter, which indicated a resolution of inflammation within 7 d. On the contrary, plasma CRH level and AWR score were increased on d 2, remained high on d 7, and returned to control level on d 14. Intraperitoneal injection of a CRH antagonist, astressin (30 mg/kg), significantly attenuated the post-inflammatory visceral hypersensitivity on d 7. Furthermore, intraperitoneal administration of CRH (3 and 10 mg/kg) mimicked the post-inflammatory visceral hypersensitivity in naive rats. CONCLUSION: These results suggest that increased peripheral CRH mediates the enhanced visceral nociception in rats recovered from experimental colitis. | en |
dc.language.iso | en | en |
dc.publisher | The WJG Press | en |
dc.subject | Corticotropin releasing hormone | en |
dc.subject | Visceral hypersensitivity | en |
dc.subject | Colitis | en |
dc.title | Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 라준호 | - |
dc.contributor.AlternativeAuthor | 성태식 | - |
dc.contributor.AlternativeAuthor | 김현주 | - |
dc.contributor.AlternativeAuthor | 김태완 | - |
dc.contributor.AlternativeAuthor | 강동묵 | - |
dc.contributor.AlternativeAuthor | 양일석 | - |
dc.identifier.doi | 10.3748/wjg.14.731 | - |
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