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Low-frequency electroacupuncture suppresses zymosan-induced peripheral inflammation via activation of sympathetic post-ganglionic neurons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyun-Woo | - |
dc.contributor.author | Kang, Suk-Yun | - |
dc.contributor.author | Yoon, Seo Yeon | - |
dc.contributor.author | Roh, Dae-Hyun | - |
dc.contributor.author | Kwon, Young-Bae | - |
dc.contributor.author | Han, Ho-Jae | - |
dc.contributor.author | Lee, Hye-Jung | - |
dc.contributor.author | Beitze, Alvin J. | - |
dc.contributor.author | Lee, Jang-Hern | - |
dc.date.accessioned | 2009-08-24T08:39:48Z | - |
dc.date.available | 2009-08-24T08:39:48Z | - |
dc.date.issued | 2007-02-24 | - |
dc.identifier.citation | Brain Res. 1148, 69-75 | en |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | https://hdl.handle.net/10371/7613 | - |
dc.description.abstract | Electroacupuncture (EA) is used to treat a variety of inflammatory diseases; however, the neurophysiological mechanisms underlying EA's anti-inflammatory effect remain unclear. Accumulating evidence suggests that the sympathetic nervous system regulates immunologic and inflammatory responses and thus we hypothesized that this system could be involved in EA's anti-inflammatory effect (EA-AI). The goal of the present study was to evaluate whether the sympathetic nervous system plays a critical role in EA-AI using a mouse air pouch inflammation model. We found that bilateral low-frequency (1 Hz) EA applied to the Zusanli acupoint significantly suppressed the number of zymosan-induced leukocytes migrating into the air pouch. Furthermore, double-labeling immunohistochemical experiments showed that EA stimulation increased Fos expression in choline acetyltransferase (ChAT)-positive sympathetic pre-ganglionic neurons in the intermediolateral region of thoracic spinal cord segments. Chemical sympathetic denervation by intraperitoneal injection of 6-hydroxydopamine (which spares sympathetic adrenal medullary innervation) significantly inhibited EA-AI. In contrast, adrenalectomy did not alter EA-AI. Finally, systemic propranolol administration significantly inhibited EA's anti-inflammatory effect, suggesting that β-adrenoceptors are involved. Collectively, these results suggest that EA produces an anti-inflammatory effect in this mouse air pouch model by activating the sympathetic nervous system leading to the release of catecholamines from post-ganglionic nerve terminals, which act on β-adrenoceptors on immune cells to inhibit their migration. | en |
dc.description.sponsorship | This work was supported by the SRC program of KOSEF (R11-2005-014). In addition, this study was supported by a Research Fund from the Research Institute for Veterinary Science (RIVS) in the College of Veterinary Medicine, Seoul National University. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Electroacupuncture | en |
dc.subject | Anti-inflammatory | en |
dc.subject | Sympathetic pre-ganglionic neuron | en |
dc.subject | Adrenalectomy | en |
dc.subject | Air pouch | en |
dc.subject | Mouse | en |
dc.title | Low-frequency electroacupuncture suppresses zymosan-induced peripheral inflammation via activation of sympathetic post-ganglionic neurons | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김현우 | - |
dc.contributor.AlternativeAuthor | 강석윤 | - |
dc.contributor.AlternativeAuthor | 윤서연 | - |
dc.contributor.AlternativeAuthor | 노대현 | - |
dc.contributor.AlternativeAuthor | 권영배 | - |
dc.contributor.AlternativeAuthor | 한호재 | - |
dc.contributor.AlternativeAuthor | 이혜정 | - |
dc.contributor.AlternativeAuthor | 이장헌 | - |
dc.identifier.doi | 10.1016/j.brainres.2007.02.030 | - |
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