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Peripheral bee venom's anti-inflammatory effect involves activation of the coeruleospinal pathway and sympathetic preganglionic neurons

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dc.contributor.authorYoon, Seo Yeon-
dc.contributor.authorKwon, Young-Bae-
dc.contributor.authorKim, Hyun-Woo-
dc.contributor.authorRoh, Dae-Hyun-
dc.contributor.authorSeo, Hyoung-Sig-
dc.contributor.authorHan, Ho-Jae-
dc.contributor.authorLee, Hye-Jung-
dc.contributor.authorBeitze, Alvin J.-
dc.contributor.authorHwang, Sun-Wook-
dc.contributor.authorLee, Jang-Hern-
dc.date.accessioned2009-08-24T08:40:21Z-
dc.date.available2009-08-24T08:40:21Z-
dc.date.issued2007-05-31-
dc.identifier.citationNeurosci. Res. 59, 51-59en
dc.identifier.issn0168-0102-
dc.identifier.urihttps://hdl.handle.net/10371/7614-
dc.description.abstractThere are several reports indicating that the locus coeruleus (LC) is capable of altering immune responses. Moreover, it is well established that the LC is the major source of descending noradrenergic system. Recently we have demonstrated that subcutaneous bee venom (BV) injection dramatically suppressed peripheral inflammation through activation of sympathetic preganglionic neurons (SPNs) leading to release of adreno-medullary catecholamines. Importantly, this BV-induced anti-inflammatory effect (BVAI) is also associated with an increase of the activity of LC. Based on these data, present study examined whether BV-induced LC activation increased the activity of SPNs and this pathway played a role in BVAI using a zymosan-induced inflammatory air pouch model in mice. Unilateral BV injection into left hind limb produced anti-inflammation and specifically increased Fos expression in SPNs of the T7–T11 (which mainly project to adrenal medulla), but not those of the T1–T6 or T12–L2 spinal cord. 6-Hydroxydopamine-induced unilateral lesion of the contralateral, but not ipsilateral (to the BV injection site) LC significantly blocked BVAI and BV-induced Fos expression in SPNs. Additionally, intrathecal administration of idazoxan (α2-adrenoceptor antagonist), blocked BVAI. These results indicate that BV-induced activation of the contralateral LC-descending noradrenergic pathway increased the activity of SPNs that project to the adrenal medulla and this pathway is necessary for BVAI.en
dc.description.sponsorshipThis research was supported by a grant (M103KV010015–06K2201-01510) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, the Republic of Korea. The publication of this manuscript was also supported by the SRC program of MOST/KOSEF (R11-2005-014) as well as the Brain Korea 21 project, in the College of Veterinary Medicine, Chonnam National University, Korea. We thank Jee-Eun Kim and Sol-Jee Park for their skilled technical contribution.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectBee venomen
dc.subjectInflammationen
dc.subjectlocus coeruleusen
dc.subjectα2-Adrenoceptoren
dc.subjectAdrenal medullaen
dc.subjectSympathetic preganglionic neuronsen
dc.titlePeripheral bee venom's anti-inflammatory effect involves activation of the coeruleospinal pathway and sympathetic preganglionic neuronsen
dc.typeArticleen
dc.contributor.AlternativeAuthor윤서연-
dc.contributor.AlternativeAuthor권영배-
dc.contributor.AlternativeAuthor김현우-
dc.contributor.AlternativeAuthor노대현-
dc.contributor.AlternativeAuthor서형식-
dc.contributor.AlternativeAuthor한호재-
dc.contributor.AlternativeAuthor이혜정-
dc.contributor.AlternativeAuthor황선욱-
dc.contributor.AlternativeAuthor이장헌-
dc.identifier.doi10.1016/j.neures.2007.05.008-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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