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CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1 alpha in Hepatoma Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Kyoung-Hwa | - |
dc.date.accessioned | 2012-05-22T04:10:42Z | - |
dc.date.available | 2012-05-22T04:10:42Z | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY; Vol.14 5; 331-336 | ko_KR |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76213 | - |
dc.description.abstract | In rapidly growing tumors, hypoxia commonly develops due to the imbalance between O(2) consumption and supply Hypoxia Inducible Factor (HIF)-1 alpha is a transcription factor responsible for tumor growth and angiogenesis in the hypoxic microenvironment, thus, its inhibition is regarded as a promising strategy for cancer therapy Given that CamKII or PARP inhibitors are emerging anticancer agents, we investigated if they have the potential to be developed as new HIF-1 alpha-targeting drugs When treating various cancer cells with the inhibitors, we found that a CamKII inhibitor, KN-62, effectively suppressed HIF-1 alpha specifically in hepatoma cells To examine the effect of KN-62 on HIF-1 alpha-driven gene expression, we analyzed the EPO-enhancer reporter activity and mRNA levels of HIF-1 alpha downstream genes, such as EPO, LOX and CA9 Both the reporter activity and the mRNA expression were repressed by KN-62 We also found that KN-62 suppressed HIF-1 alpha by impairing synthesis of HIF-1 alpha protein Based on these results, we propose that KN-62 is a candidate as a HIF-1 alpha-targeting anticancer agent | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | ko_KR |
dc.subject | CaMKII | ko_KR |
dc.subject | KN-62 | ko_KR |
dc.subject | HIF1-alpha | ko_KR |
dc.subject | Hypoxia | ko_KR |
dc.subject | Hepatocellular carcinoma | ko_KR |
dc.title | CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1 alpha in Hepatoma Cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이경화 | - |
dc.identifier.doi | 10.4196/kjpp.2010.14.5.331 | - |
dc.citation.journaltitle | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
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