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Identification and analysis of dominant negative mutants of RAIDD and PIDD

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dc.contributor.authorJang, Tae-Ho-
dc.contributor.authorBae, Ju Young-
dc.contributor.authorPark, Ok Kyoung-
dc.contributor.authorKim, Ji Hoe-
dc.contributor.authorPark, Hyun Ho-
dc.contributor.authorJeon, Ju-Hong-
dc.contributor.authorCho, Kyung-Hyun-
dc.date.accessioned2012-05-22T04:39:33Z-
dc.date.available2012-05-22T04:39:33Z-
dc.date.issued2010-07-
dc.identifier.citationBIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS; Vol.1804 7; 1557-1563ko_KR
dc.identifier.issn1570-9639-
dc.identifier.urihttps://hdl.handle.net/10371/76220-
dc.description.abstractCaspases are cysteine proteases that are essential during the initiation and execution of apoptosis and inflammation. The formation of large oligomeric protein complexes is critical to the activation of caspases in apoptotic and inflammatory signaling pathways. These oligomeric protein complexes function as a platform to recruit caspases, which leads to caspase activation via a proximity-induced mechanism. One well-known oligomeric caspase-activating complex is the PIDDosome for caspase-2 activation, which is composed of 3 protein components, PIDD, RAIDD and Caspase-2. Despite the significant role that caspase-2 activated by PIDDosome plays during genotoxic stress-induced apoptosis, the oligomerization mechanism and the method by which the caspase-activating process is mediated by the formation of PIDDosome is currently not well understood. Here, we show that the assembly mechanism of the core of PIDDosome is time-dependent and salt concentration-dependent. In addition, we demonstrate that point mutations on RAIDD (R147E) and on PLOD (Y814A) exert a dominant negative effect on the formation of the PIDDosome, and that this effect cannot be applied after the PIDDosome has been formed. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER SCIENCE BVko_KR
dc.subjectApoptosisko_KR
dc.subjectRAIDDko_KR
dc.subjectDominant negative mutantko_KR
dc.subjectPIDD PIDDosomeko_KR
dc.subjectDISCko_KR
dc.subjectInflammationko_KR
dc.subjectApoptosomeko_KR
dc.subjectCaspase-2ko_KR
dc.titleIdentification and analysis of dominant negative mutants of RAIDD and PIDDko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor장태호-
dc.contributor.AlternativeAuthor김지회-
dc.contributor.AlternativeAuthor조경현-
dc.contributor.AlternativeAuthor전주홍-
dc.contributor.AlternativeAuthor박현호-
dc.contributor.AlternativeAuthor박옥경-
dc.contributor.AlternativeAuthor배주영-
dc.identifier.doi10.1016/j.bbapap.2010.04.006-
dc.citation.journaltitleBIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS-
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
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