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Phentolamine Inhibits the Pacemaker Activity of Mouse Interstitial Cells of Cajal by Activating ATP-Sensitive K(+) Channels
DC Field | Value | Language |
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dc.contributor.author | Ahn, Seung Whan | - |
dc.contributor.author | Kim, Sang Hun | - |
dc.contributor.author | Choi, Seok | - |
dc.contributor.author | Kim, Jin Ho | - |
dc.contributor.author | Yeum, Cheol Ho | - |
dc.contributor.author | Sun, Jae Myeong | - |
dc.contributor.author | Jun, Jae Yeoul | - |
dc.contributor.author | So, Insuk | - |
dc.contributor.author | Wie, Hee Wook | - |
dc.date.accessioned | 2012-05-22T05:35:00Z | - |
dc.date.available | 2012-05-22T05:35:00Z | - |
dc.date.issued | 2010-03-10 | - |
dc.identifier.citation | ARCHIVES OF PHARMACAL RESEARCH; Vol.33 3; 479-489 | ko_KR |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76229 | - |
dc.description.abstract | The aim of this study was to clarify if phentolamine has proven effects on the pacemaker activities of interstitial cells of Cajal (ICC) from the mouse small intestine involving the ATP-sensitive K(+) channels and adrenergic receptor. The actions of phentolamine on pacemaker activities were investigated using whole-cell patch-clamp technique and intracellular Ca(2+) analysis at 30 degrees C in cultured mouse intestinal ICC. ICC generated spontaneous pacemaker currents at a holding potential of -70 mV. Treatment with phentolamine reduced the frequency and amplitude of the pacemaker currents and increased the resting outward currents. Moreover, under current clamping (I = 0), phentolamine hyperpolarized the ICC membrane and decreased the amplitude of the pacemaker potentials. We also observed that phentolamine inhibited spontaneous [Ca(2+)](i) oscillations in ICC. The alpha-adrenergic drugs prazosin, yohimbine, methoxamine, and clonidine had no effect on ICC intestinal pacemaker activity and did not block phentolamine-induced effects. Phentolamine-induced effects on the pacemaker currents and the pacemaker potentials were significantly inhibited by ATP sensitive K(+) channel blocker glibenclamide, but not by TEA, apamin, or 4-aminopyridine. In addition, the NO synthase inhibitor, L-NAME and the guanylate cyclase inhibitor, ODQ were incapable of blocking the phentolamine-induced effects. These results demonstrate that phentolamine regulates the pacemaker activity of ICC via ATP-sensitive K(+) channel activation. Phentolamine could act through an adrenergic receptor- and also through NO-independent mechanism that involves intracellular Ca(2+) signaling. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PHARMACEUTICAL SOC KOREA | ko_KR |
dc.subject | Interstitial cells of Cajal | ko_KR |
dc.subject | Pacemaker activities | ko_KR |
dc.subject | ATP-sensitive K(+) channels | ko_KR |
dc.subject | Phentolamine | ko_KR |
dc.title | Phentolamine Inhibits the Pacemaker Activity of Mouse Interstitial Cells of Cajal by Activating ATP-Sensitive K(+) Channels | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 안승완 | - |
dc.contributor.AlternativeAuthor | 위희욱 | - |
dc.contributor.AlternativeAuthor | 소인석 | - |
dc.contributor.AlternativeAuthor | 전재열 | - |
dc.contributor.AlternativeAuthor | 선재명 | - |
dc.contributor.AlternativeAuthor | 염철호 | - |
dc.contributor.AlternativeAuthor | 김상훈 | - |
dc.contributor.AlternativeAuthor | 최석 | - |
dc.contributor.AlternativeAuthor | 김진호 | - |
dc.identifier.doi | 10.1007/s12272-010-0319-x | - |
dc.citation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.description.citedreference | Epperson A, 2000, AM J PHYSIOL-CELL PH, V279, pC529 | - |
dc.description.citedreference | Deka DK, 2004, EUR J PHARMACOL, V492, P13, DOI 10.1016/j.ejphar.2004.03.057 | - |
dc.description.citedreference | Silva LFG, 2005, INT J IMPOT RES, V17, P27, DOI 10.1038/sj.ijir.3901269 | - |
dc.description.citedreference | Rodrigo GC, 2005, CURR PHARM DESIGN, V11, P1915 | - |
dc.description.citedreference | Jun JY, 2005, BRIT J PHARMACOL, V144, P242, DOI 10.1038/sj.bjp.0706074 | - |
dc.description.citedreference | Kito Y, 2005, AM J PHYSIOL-CELL PH, V288, pC710, DOI 10.1152/ajpcell.00361.2004 | - |
dc.description.citedreference | Choi S, 2006, CELL PHYSIOL BIOCHEM, V18, P187 | - |
dc.description.citedreference | Sanders KM, 2006, ANNU REV PHYSIOL, V68, P307, DOI 10.1146/annurev.physiol.68.040504.094718 | - |
dc.description.citedreference | Ward SM, 2006, J PHYSIOL-LONDON, V576, P675, DOI 10.1113/jphysiol.2006.117390 | - |
dc.description.citedreference | Park CG, 2007, N-S ARCH PHARMACOL, V376, P175, DOI 10.1007/s00210-007-0187-1 | - |
dc.description.citedreference | Hoy M, 2001, J BIOL CHEM, V276, P924 | - |
dc.description.citedreference | Vemulapalli S, 2001, FUNDAM CLIN PHARM, V15, P1 | - |
dc.description.citedreference | Jun JY, 2001, AM J PHYSIOL-CELL PH, V281, pC857 | - |
dc.description.citedreference | Brayden JE, 2002, CLIN EXP PHARMACOL P, V29, P312 | - |
dc.description.citedreference | Jun JY, 2004, BRIT J PHARMACOL, V141, P670, DOI 10.1038/sj.bjp.0705665 | - |
dc.description.citedreference | Mannhold R, 2004, MED RES REV, V24, P213, DOI 10.1002/med.10060 | - |
dc.description.citedreference | Suzuki H, 2000, J PHYSIOL-LONDON, V525, P105 | - |
dc.description.citedreference | Proks P, 1997, P NATL ACAD SCI USA, V94, P11716 | - |
dc.description.citedreference | Kubo M, 1997, J PHYSIOL-LONDON, V503, P489 | - |
dc.description.citedreference | Shepherd RM, 1996, BRIT J PHARMACOL, V119, P911 | - |
dc.description.citedreference | MURPHY ME, 1995, J PHYSIOL-LONDON, V486, P47 | - |
dc.description.citedreference | HUIZINGA JD, 1995, NATURE, V373, P347 | - |
dc.description.citedreference | Rustenbeck I, 1995, EXP CLIN ENDOCR DIAB, V103, P42 | - |
dc.description.citedreference | WARD SM, 1994, J PHYSIOL-LONDON, V480, P91 | - |
dc.description.citedreference | ZHANG L, 1994, AM J PHYSIOL, V267, pG494 | - |
dc.description.citedreference | WILDE AAM, 1994, CARDIOVASC RES, V28, P847 | - |
dc.description.citedreference | QUAYLE JM, 1994, J PHYSIOL-LONDON, V475, P9 | - |
dc.description.citedreference | JONAS JC, 1992, BRIT J PHARMACOL, V107, P8 | - |
dc.description.citedreference | SCHWIETERT R, 1992, EUR J PHARMACOL, V211, P87 | - |
dc.description.citedreference | SMALL RC, 1992, BRAZ J MED BIOL RES, V25, P983 | - |
dc.description.citedreference | PLANT TD, 1991, BRIT J PHARMACOL, V104, P385 | - |
dc.description.citedreference | DUNNE MJ, 1991, BRIT J PHARMACOL, V103, P1847 | - |
dc.description.citedreference | HOFFMANN BB, 1991, PHARMACOL BASIS THER, pCH10 | - |
dc.description.citedreference | PLANT TD, 1990, BRIT J PHARMACOL, V101, P115 | - |
dc.description.tc | 2 | - |
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