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Receptor tyrosine and MAP kinase are involved in effects of H(2)O(2) on interstitial cells of Cajal in murine intestine
DC Field | Value | Language |
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dc.contributor.author | Choi, Seok | - |
dc.contributor.author | Yeum, Cheol Ho | - |
dc.contributor.author | Kim, Young Dae | - |
dc.contributor.author | Park, Jong-Seong | - |
dc.contributor.author | Jeong, Han-Seong | - |
dc.contributor.author | Kim, Man Yoo | - |
dc.contributor.author | Park, Chan Guk | - |
dc.contributor.author | Kim, Byung Joo | - |
dc.contributor.author | Kim, Ki Whan | - |
dc.contributor.author | Jun, Jae Yeoul | - |
dc.contributor.author | So, Insuk | - |
dc.date.accessioned | 2012-05-22T06:29:18Z | - |
dc.date.available | 2012-05-22T06:29:18Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE; Vol.14, No 1-2; 257-266 | ko_KR |
dc.identifier.issn | 1582-1838 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76239 | - |
dc.description.abstract | Hydrogen peroxide (H(2)O(2)) is involved in intestinal motility through changes of smooth muscle activity. However, there is no report as to the modulatory effects of H(2)O(2) on interstitial cells of Cajal (ICC). We investigated the H(2)O(2) effects and signal transductions to determine whether the intestinal motility can be modulated through ICC. We performed whole-cell patch clamp in cultured ICC from murine intestine and molecular analyses. H(2)O(2) hyperpolarized the membrane and inhibited pacemaker currents. These effects were inhibited by glibenclamide, an inhibitor of ATP-sensitive K+ (K(ATP)) channels. The free-radical scavenger catalase inhibited the H(2)O(2)-induced effects. MAFP and AACOCF(3) (a cytosolic phospholipase A(2) inhibitors) or SC-560 and NS-398 (a selective COX-1 and 2 inhibitor) or AH6809 (an EP(2) receptor antagonist) inhibited the H(2)O(2)-induced effects. PD98059 (a mitogen activated/ERK-activating protein kinase inhibitor) inhibited the H(2)O(2)-induced effects, though SB-203580 (a p38 MAPK inhibitor) or a JNK inhibitor did not affect. H(2)O(2)-induced effects could not be inhibited by LY-294002 (an inhibitor of PI(3)-kinases), calphostin C (a protein kinase C inhibitor) or SQ-22536 (an adenylate cyclase inhibitor). Adenoviral infection analysis revealed H(2)O(2) stimulated tyrosine kinase activity and AG 1478 (an antagonist of epidermal growth factor receptor tyrosine kinase) inhibited the H(2)O(2)-induced effects. These results suggest H(2)O(2) can modulate ICC pacemaker activity and this occur by the activation of K(ATP) channels through PGE(2) production via receptor tyrosine kinase-dependent MAP kinase activation. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.subject | hydrogen peroxide | ko_KR |
dc.subject | pacemaker currents | ko_KR |
dc.subject | cyclooxygenase | ko_KR |
dc.subject | MAP kinase | ko_KR |
dc.subject | receptor tyrosine kinase | ko_KR |
dc.subject | interstitial cells of Cajal | ko_KR |
dc.title | Receptor tyrosine and MAP kinase are involved in effects of H(2)O(2) on interstitial cells of Cajal in murine intestine | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최석 | - |
dc.contributor.AlternativeAuthor | 전재열 | - |
dc.contributor.AlternativeAuthor | 김기완 | - |
dc.contributor.AlternativeAuthor | 소인석 | - |
dc.contributor.AlternativeAuthor | 박찬국 | - |
dc.contributor.AlternativeAuthor | 김만유 | - |
dc.contributor.AlternativeAuthor | 박종성 | - |
dc.contributor.AlternativeAuthor | 김병주 | - |
dc.contributor.AlternativeAuthor | 정한성 | - |
dc.contributor.AlternativeAuthor | 김영대 | - |
dc.contributor.AlternativeAuthor | 염철호 | - |
dc.identifier.doi | 10.1111/j.1582-4934.2008.00403.x | - |
dc.citation.journaltitle | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | - |
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dc.description.tc | 0 | - |
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