Publications

Detailed Information

Identification of TRPM7 channels in human intestinal interstitial cells of Cajal

DC Field Value Language
dc.contributor.authorKim, Byung Joo-
dc.contributor.authorPark, Kyu Joo-
dc.contributor.authorKim, Hyung Woo-
dc.contributor.authorChoi, Seok-
dc.contributor.authorSo, Insuk-
dc.contributor.authorKim, Seon Jeong-
dc.contributor.authorJeon, Ju-Hong-
dc.contributor.authorChang, In Youb-
dc.contributor.authorJun, Jae Yeoul-
dc.date.accessioned2012-05-22T06:34:38Z-
dc.date.available2012-05-22T06:34:38Z-
dc.date.issued2009-12-14-
dc.identifier.citationWORLD JOURNAL OF GASTROENTEROLOGY; Vol.15 46; 5799-5804ko_KR
dc.identifier.issn1007-9327-
dc.identifier.urihttps://hdl.handle.net/10371/76240-
dc.description.abstractAIM: To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 (TRPM7) in the human gastrointestinal (GI) tract. METHODS: Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajal (ICCs). RESULTS: The human GI tract generated slow electrical waves and had ICCs which functioned as pacemaker cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB (2-aminoethoxydiphenyl borate) and La(3+), TRPM7 channel blockers, inhibited the slow waves. Also, TRPM7 channels were expressed in ICCs in human tissue. CONCLUSION: These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the generation of the slow waves. (C) 2009 The WJG Press and Baishideng. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherW J G PRESSko_KR
dc.subjectElectrophysiologyko_KR
dc.subjectGastrointestinal tractko_KR
dc.subjectHumanko_KR
dc.subjectInterstitial cells of Cajalko_KR
dc.subjectTRPM cation channelsko_KR
dc.subjectTransient receptor potential melastatin-type 7 proteinko_KR
dc.titleIdentification of TRPM7 channels in human intestinal interstitial cells of Cajalko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박규주-
dc.contributor.AlternativeAuthor김형우-
dc.contributor.AlternativeAuthor김병주-
dc.contributor.AlternativeAuthor최석-
dc.contributor.AlternativeAuthor소인석-
dc.contributor.AlternativeAuthor김선정-
dc.contributor.AlternativeAuthor전주홍-
dc.contributor.AlternativeAuthor장인엽-
dc.contributor.AlternativeAuthor전재열-
dc.identifier.doi10.3748/wjg.15.5799-
dc.citation.journaltitleWORLD JOURNAL OF GASTROENTEROLOGY-
dc.description.citedreferenceKoh SD, 2002, J PHYSIOL-LONDON, V540, P803-
dc.description.citedreferenceSanders KM, 1999, NEUROGASTROENT MOTIL, V11, P311-
dc.description.citedreferenceKomuro T, 1999, ARCH HISTOL CYTOL, V62, P295-
dc.description.citedreferenceOrdog T, 1999, J PHYSIOL-LONDON, V518, P257-
dc.description.citedreferenceDickens EJ, 1999, J PHYSIOL-LONDON, V514, P515-
dc.description.citedreferenceFarrugia G, 1999, ANNU REV PHYSIOL, V61, P45-
dc.description.citedreferenceKoh SD, 1998, J PHYSIOL-LONDON, V513, P203-
dc.description.citedreferenceThomsen L, 1998, NAT MED, V4, P848-
dc.description.citedreferenceHuizinga JD, 1997, TRENDS PHARMACOL SCI, V18, P393-
dc.description.citedreferencePrakriya M, 2002, J GEN PHYSIOL, V119, P487-
dc.description.citedreferenceHuizinga JD, 2002, GASTROENTEROLOGY, V123, P1627, DOI 10.1053/gast.2002.36549-
dc.description.citedreferenceMonteilh-Zoller MK, 2003, J GEN PHYSIOL, V121, P49, DOI 10.1085/jgp.20028740-
dc.description.citedreferenceSchmitz C, 2003, CELL, V114, P191-
dc.description.citedreferenceStrege PR, 2003, AM J PHYSIOL-GASTR L, V285, pG1111, DOI 10.1152/ajpgi.00152.2003-
dc.description.citedreferenceClapham DE, 2003, NATURE, V426, P517, DOI 10.1038/nature02196-
dc.description.citedreferenceAarts M, 2003, CELL, V115, P863-
dc.description.citedreferenceVriens J, 2004, PFLUG ARCH EUR J PHY, V449, P213, DOI 10.1007/s00424-004-1314-1-
dc.description.citedreferenceElizondo MR, 2005, CURR BIOL, V15, P667-
dc.description.citedreferenceKim BJ, 2005, GASTROENTEROLOGY, V129, P1504, DOI 10.1053/j.gastro.2005.08.016-
dc.description.citedreferenceLee HT, 2007, GASTROENTEROLOGY, V132, P1852, DOI 10.1053/j.gastro.2007.02.049-
dc.description.citedreferenceBrauchi S, 2008, P NATL ACAD SCI USA, V105, P8304, DOI 10.1073/pnas.0800881105-
dc.description.citedreferenceSahni J, 2008, CELL METAB, V8, P84, DOI 10.1016/j.cmet.2008.06.002-
dc.description.citedreferenceKim BJ, 2008, CANCER SCI, V99, P2502, DOI 10.1111/j.1349-7006.2008.00982.x-
dc.description.citedreferenceAbed E, 2009, AM J PHYSIOL-CELL PH, V297, pC360, DOI 10.1152/ajpcell.00614.2008-
dc.description.citedreferenceGuilbert A, 2009, AM J PHYSIOL-CELL PH, V297, pC493, DOI 10.1152/ajpcell.00624.2008-
dc.description.citedreferenceTorihashi S, 1997, GASTROENTEROLOGY, V112, P144-
dc.description.citedreferenceSanders KM, 1996, GASTROENTEROLOGY, V111, P492-
dc.description.citedreferenceTORIHASHI S, 1995, CELL TISSUE RES, V280, P97-
dc.description.citedreferenceHUIZINGA JD, 1995, NATURE, V373, P347-
dc.description.citedreferenceWARD SM, 1994, J PHYSIOL-LONDON, V480, P91-
dc.description.citedreferenceMAEDA H, 1992, DEVELOPMENT, V116, P369-
dc.description.citedreferenceLANGTON P, 1989, P NATL ACAD SCI USA, V86, P7280-
dc.description.citedreferenceSZURSZEWSKI JH, 1987, PHYSL GASTROINTESTIN, P383-
dc.description.citedreferenceTOMITA T, 1981, SMOOTH MUSCLE ASSESS, P127-
dc.description.tc4-
Appears in Collections:
Files in This Item:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share