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Concurrent Langerhans Cell Histiocytosis and B-Lineage Lymphoid Proliferation in the Bone Marrow
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Miyoung | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Lee, Dong Soon | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.date.accessioned | 2012-05-23T01:50:30Z | - |
dc.date.available | 2012-05-23T01:50:30Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.citation | KOREAN JOURNAL OF LABORATORY MEDICINE; Vol.29 5; 402-405 | ko_KR |
dc.identifier.issn | 1598-6535 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76301 | - |
dc.description.abstract | We present three cases of concurrent Langerhans cell histiocytosis (LCH) and B-lineage lymphoid cell infiltrations and/or nodules in the bone marrow. The first patient was a 25-month-old boy who presented with LCH on the right shoulder and multiple osteolytic lesions. Bone marrow biopsy showed the presence of LCH and two large lymphoid nodules of B-lineage, which were located in the paratrabecular region. Both LCH and the lymphoid nodules resolved after treatment with prednisone, vinblastine, methotrexate, and cyclophosphamide. The second patient was a 7-month-old girl who presented with LCH in the scalp and bone marrow. In spite of the treatment, a follow-up bone marrow analysis performed after 16 months showed LCH and increased B-lineage lymphoid cells in the interstitial area, The third patient was a 26-month-old girl, and imaging studies revealed reddish skin lesions and multiple osteolytic lesions. Skin biopsy and bone marrow biopsy did not show the presence of LCH; however, we initiated the treatment on the basis of the results of imaging studies. The follow-up study after 6 months showed the presence of LCH and large, patchy infiltration of B-lymphoid cells. We report three rare cases of concurrent bone marrow involvement of LCH and B-lineage lymphoid proliferation, which strongly suggest lymphoid malignancy. Further, clonal changes should be studied to elucidate the common pathogenic mechanism between the two diseases. (Korean J Lab Med 2009;29:402-5) | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC LABORATORY MEDICINE | ko_KR |
dc.subject | Langerhans cell histiocytosis | ko_KR |
dc.subject | Lymphoid proliferation | ko_KR |
dc.subject | Bone marrow | ko_KR |
dc.title | Concurrent Langerhans Cell Histiocytosis and B-Lineage Lymphoid Proliferation in the Bone Marrow | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김미영 | - |
dc.contributor.AlternativeAuthor | 안효섭 | - |
dc.contributor.AlternativeAuthor | 이동순 | - |
dc.contributor.AlternativeAuthor | 신희영 | - |
dc.contributor.AlternativeAuthor | 강현진 | - |
dc.identifier.doi | 10.3343/kjlm.2009.29.5.402 | - |
dc.citation.journaltitle | KOREAN JOURNAL OF LABORATORY MEDICINE | - |
dc.description.citedreference | Licci S, 2008, ANN HEMATOL, V87, P855, DOI 10.1007/s00277-008-0489-5 | - |
dc.description.citedreference | SWERDLOW SH, 2008, WHO CLASSIFICATION T, P358 | - |
dc.description.citedreference | Feldman AL, 2005, LANCET ONCOL, V6, P435 | - |
dc.description.citedreference | Adu-Poku K, 2005, J CLIN PATHOL, V58, P104, DOI 10.1136/jcp.2003.015537 | - |
dc.description.citedreference | Thiele J, 1999, J CLIN PATHOL, V52, P294 | - |
dc.description.tc | 0 | - |
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