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The LRRK2 G2385R variant is a risk factor for sporadic Parkinson`s disease in the Korean population
DC Field | Value | Language |
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dc.contributor.author | Kim, Jong-Min | - |
dc.contributor.author | Lee, Jee-Young | - |
dc.contributor.author | Kim, Ji Seon | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Cho, Jin-Hwan | - |
dc.contributor.author | Jeon, Beom S. | - |
dc.contributor.author | Park, Sung Sup | - |
dc.contributor.author | Shin, Eun-Soon | - |
dc.date.accessioned | 2012-05-23T01:57:41Z | - |
dc.date.available | 2012-05-23T01:57:41Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | PARKINSONISM & RELATED DISORDERS; Vol.16 2; 85-88 | ko_KR |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76304 | - |
dc.description.abstract | The G2385R (SNP accession no. rs34778348) and R1628P (rs33949390) variants Of leucine-rich repeat kinase 2 (LRRK2, PARK8) are emerging as an important risk factor for Parkinson`s disease (PD) in the ethnic Chinese and Japanese Populations. The purpose of this study was to investigate whether these variants are a genetic risk factor in sporadic PD patients in the Korean population. A total of 923 patients and 422 healthy subjects were included. The variants were screened by a SNaPshot assay. The LRRK2 G2385R variant was detected in 82 PD patients (8.9%, two homozygous and 80 heterozygous) and in 21 normal controls (5.0%, all heterozygous). The frequency of the LRRK2 G2385R variant in PD was significantly higher than in normal controls (adjusted odds ratio 1.83, p = 0.0170, 95% confidence interval 1.11-3.00). There were no differences in the mean age at onset or gender between the G2385R carriers and the non-carriers in PD patients. The LRRK2 R1628P variant was very rare (0.78% in patients versus 0.26% in controls) in the tested 384 patient-control pairs, and was not a significant risk factor. This Study Supports that the LRRK2 G2385R variant may be a genetic risk factor for sporadic PD in the Korean population. (C) 2009 Elsevier Ltd. All rights reserved. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCI LTD | ko_KR |
dc.subject | LRRK2 | ko_KR |
dc.subject | G2385R | ko_KR |
dc.subject | R1628P | ko_KR |
dc.subject | Parkinson`s disease | ko_KR |
dc.subject | Polymorphism | ko_KR |
dc.title | The LRRK2 G2385R variant is a risk factor for sporadic Parkinson`s disease in the Korean population | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김종민 | - |
dc.contributor.AlternativeAuthor | 김지선 | - |
dc.contributor.AlternativeAuthor | 이지영 | - |
dc.contributor.AlternativeAuthor | 김희진 | - |
dc.contributor.AlternativeAuthor | 신은순 | - |
dc.contributor.AlternativeAuthor | 박성섭 | - |
dc.contributor.AlternativeAuthor | 전범석 | - |
dc.contributor.AlternativeAuthor | 조진환 | - |
dc.identifier.doi | 10.1016/j.parkreldis.2009.10.004 | - |
dc.citation.journaltitle | PARKINSONISM & RELATED DISORDERS | - |
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dc.description.tc | 2 | - |
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