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The LRRK2 G2385R variant is a risk factor for sporadic Parkinson`s disease in the Korean population

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dc.contributor.authorKim, Jong-Min-
dc.contributor.authorLee, Jee-Young-
dc.contributor.authorKim, Ji Seon-
dc.contributor.authorKim, Hee Jin-
dc.contributor.authorCho, Jin-Hwan-
dc.contributor.authorJeon, Beom S.-
dc.contributor.authorPark, Sung Sup-
dc.contributor.authorShin, Eun-Soon-
dc.date.accessioned2012-05-23T01:57:41Z-
dc.date.available2012-05-23T01:57:41Z-
dc.date.issued2010-02-
dc.identifier.citationPARKINSONISM & RELATED DISORDERS; Vol.16 2; 85-88ko_KR
dc.identifier.issn1353-8020-
dc.identifier.urihttps://hdl.handle.net/10371/76304-
dc.description.abstractThe G2385R (SNP accession no. rs34778348) and R1628P (rs33949390) variants Of leucine-rich repeat kinase 2 (LRRK2, PARK8) are emerging as an important risk factor for Parkinson`s disease (PD) in the ethnic Chinese and Japanese Populations. The purpose of this study was to investigate whether these variants are a genetic risk factor in sporadic PD patients in the Korean population. A total of 923 patients and 422 healthy subjects were included. The variants were screened by a SNaPshot assay. The LRRK2 G2385R variant was detected in 82 PD patients (8.9%, two homozygous and 80 heterozygous) and in 21 normal controls (5.0%, all heterozygous). The frequency of the LRRK2 G2385R variant in PD was significantly higher than in normal controls (adjusted odds ratio 1.83, p = 0.0170, 95% confidence interval 1.11-3.00). There were no differences in the mean age at onset or gender between the G2385R carriers and the non-carriers in PD patients. The LRRK2 R1628P variant was very rare (0.78% in patients versus 0.26% in controls) in the tested 384 patient-control pairs, and was not a significant risk factor. This Study Supports that the LRRK2 G2385R variant may be a genetic risk factor for sporadic PD in the Korean population. (C) 2009 Elsevier Ltd. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER SCI LTDko_KR
dc.subjectLRRK2ko_KR
dc.subjectG2385Rko_KR
dc.subjectR1628Pko_KR
dc.subjectParkinson`s diseaseko_KR
dc.subjectPolymorphismko_KR
dc.titleThe LRRK2 G2385R variant is a risk factor for sporadic Parkinson`s disease in the Korean populationko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김종민-
dc.contributor.AlternativeAuthor김지선-
dc.contributor.AlternativeAuthor이지영-
dc.contributor.AlternativeAuthor김희진-
dc.contributor.AlternativeAuthor신은순-
dc.contributor.AlternativeAuthor박성섭-
dc.contributor.AlternativeAuthor전범석-
dc.contributor.AlternativeAuthor조진환-
dc.identifier.doi10.1016/j.parkreldis.2009.10.004-
dc.citation.journaltitlePARKINSONISM & RELATED DISORDERS-
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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