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The Relationship between Lewis/Secretor Genotypes and Serum Carbohydrate Antigen 19-9 Levels in a Korean Population

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dc.contributor.authorPark, Hyung-Doo-
dc.contributor.authorPark, Kyoung Un-
dc.contributor.authorSong, Junghan-
dc.contributor.authorKi, Chang-Seok-
dc.contributor.authorKim, Jin Q.-
dc.contributor.authorHan, Kyou Sup-
dc.date.accessioned2012-05-23T02:00:08Z-
dc.date.available2012-05-23T02:00:08Z-
dc.date.issued2010-02-
dc.identifier.citationKOREAN JOURNAL OF LABORATORY MEDICINE; Vol.30 1; 51-57ko_KR
dc.identifier.issn1598-6535-
dc.identifier.urihttps://hdl.handle.net/10371/76306-
dc.description.abstractBackground : The Lewis histo-blood group system consists of 2 major antigens-Le(a) and Le(b)-and a sialyl Lewis antigen-carbohyd rate antigen (CA) 19-9. We investigated the distribution of Lewis genotypes and evaluated the relationship between the Lewis/Secretor genotypes and the serum level of CA 19-9 in a Korean population to identify whether the serum CA 19-9 levels are influenced by the Lewis/Secretor genotypes. Methods : The study included 242 individuals who had no malignancies. Lewis genotyping was performed for the 59T>G, 508G>A and 1067T>A polymorphic sites. The Secretor genotype was determined through analysis of the 357C>T and 385A>T polymorphic sites and the fusion gene. Serum CA 19-9 level was analyzed using an electrochemiluminescence immunoassay. Results : Individuals carrying the 3 common genotypes-Le/Le, Le/le(59,508), and Le/le(59,1067)-accounted for 95% of the study population. In the Korean population, the allelic frequencies of Le, Le(59)le(59,508) and le(59,1067) were 0.731, 0.010, 0.223, and 0.035, respectiveiy. We found a significant difference in serum CA 19-9 concentrations among the 9 LewislSecretor genotype groups (P<0.001). The serum CA 19-9 levels in subjects with genotype groups 1 and 2 (Le/- and se/se) were higher than those with genotype groups 3-6 (Le/- and Se/-; 15.63 vs 6.64 kU/L, P<0.001). Conclusions : Le/Le(59,508), and Le/le(59,1067) are frequent Lewis genotypes in Koreans. Because serum CA 19-9 levels are significantly influenced by the LewislSecretor genotypes, caution is suggested when interpreting the serum CA 19-9 levels. (Korean J Lab Med 2010;30:51-7)ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN SOC LABORATORY MEDICINEko_KR
dc.subjectLewis genotypeko_KR
dc.subjectKorean populationko_KR
dc.subjectLewis/Secretor genotypeko_KR
dc.subjectCA 19-9ko_KR
dc.titleThe Relationship between Lewis/Secretor Genotypes and Serum Carbohydrate Antigen 19-9 Levels in a Korean Populationko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박형두-
dc.contributor.AlternativeAuthor박경운-
dc.contributor.AlternativeAuthor송정한-
dc.contributor.AlternativeAuthor기창석-
dc.contributor.AlternativeAuthor한규섭-
dc.contributor.AlternativeAuthor김진규-
dc.identifier.doi10.3343/kjlm.2010.30.1.51-
dc.citation.journaltitleKOREAN JOURNAL OF LABORATORY MEDICINE-
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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