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The Relationship between Lewis/Secretor Genotypes and Serum Carbohydrate Antigen 19-9 Levels in a Korean Population
DC Field | Value | Language |
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dc.contributor.author | Park, Hyung-Doo | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Song, Junghan | - |
dc.contributor.author | Ki, Chang-Seok | - |
dc.contributor.author | Kim, Jin Q. | - |
dc.contributor.author | Han, Kyou Sup | - |
dc.date.accessioned | 2012-05-23T02:00:08Z | - |
dc.date.available | 2012-05-23T02:00:08Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | KOREAN JOURNAL OF LABORATORY MEDICINE; Vol.30 1; 51-57 | ko_KR |
dc.identifier.issn | 1598-6535 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76306 | - |
dc.description.abstract | Background : The Lewis histo-blood group system consists of 2 major antigens-Le(a) and Le(b)-and a sialyl Lewis antigen-carbohyd rate antigen (CA) 19-9. We investigated the distribution of Lewis genotypes and evaluated the relationship between the Lewis/Secretor genotypes and the serum level of CA 19-9 in a Korean population to identify whether the serum CA 19-9 levels are influenced by the Lewis/Secretor genotypes. Methods : The study included 242 individuals who had no malignancies. Lewis genotyping was performed for the 59T>G, 508G>A and 1067T>A polymorphic sites. The Secretor genotype was determined through analysis of the 357C>T and 385A>T polymorphic sites and the fusion gene. Serum CA 19-9 level was analyzed using an electrochemiluminescence immunoassay. Results : Individuals carrying the 3 common genotypes-Le/Le, Le/le(59,508), and Le/le(59,1067)-accounted for 95% of the study population. In the Korean population, the allelic frequencies of Le, Le(59)le(59,508) and le(59,1067) were 0.731, 0.010, 0.223, and 0.035, respectiveiy. We found a significant difference in serum CA 19-9 concentrations among the 9 LewislSecretor genotype groups (P<0.001). The serum CA 19-9 levels in subjects with genotype groups 1 and 2 (Le/- and se/se) were higher than those with genotype groups 3-6 (Le/- and Se/-; 15.63 vs 6.64 kU/L, P<0.001). Conclusions : Le/Le(59,508), and Le/le(59,1067) are frequent Lewis genotypes in Koreans. Because serum CA 19-9 levels are significantly influenced by the LewislSecretor genotypes, caution is suggested when interpreting the serum CA 19-9 levels. (Korean J Lab Med 2010;30:51-7) | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KOREAN SOC LABORATORY MEDICINE | ko_KR |
dc.subject | Lewis genotype | ko_KR |
dc.subject | Korean population | ko_KR |
dc.subject | Lewis/Secretor genotype | ko_KR |
dc.subject | CA 19-9 | ko_KR |
dc.title | The Relationship between Lewis/Secretor Genotypes and Serum Carbohydrate Antigen 19-9 Levels in a Korean Population | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박형두 | - |
dc.contributor.AlternativeAuthor | 박경운 | - |
dc.contributor.AlternativeAuthor | 송정한 | - |
dc.contributor.AlternativeAuthor | 기창석 | - |
dc.contributor.AlternativeAuthor | 한규섭 | - |
dc.contributor.AlternativeAuthor | 김진규 | - |
dc.identifier.doi | 10.3343/kjlm.2010.30.1.51 | - |
dc.citation.journaltitle | KOREAN JOURNAL OF LABORATORY MEDICINE | - |
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dc.description.tc | 0 | - |
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