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Antituberculosis medication as a possible epigenetic factor of Leber`s hereditary optic neuropathy

Cited 18 time in Web of Science Cited 23 time in Scopus
Authors
Seo, Je Hyun; Hwang, Jeong-Min; Park, Sung Sup
Issue Date
2010-06
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY; Vol.38 4; 363-366
Keywords
antituberculosis medicationLeber`s hereditary optic neuropathyepigenetic factor
Abstract
Purpose: To investigate if antituberculosis medication including ethambutol could be a possible epigenetic factor in visual loss in Leber`s hereditary optic neuropathy (LHON). Methods: The authors reviewed the medical records of 46 patients registered at Bundang Seoul National University Hospital from 2002 to 2006, who developed the typical clinical neuro-ophthalmologic features of LHON and possessed a mtDNA mutation at nucleotide 11778, 14484, 3460 or 4171. Results: Three of the 46 patients developed visual loss while taking antituberculosis medication. These three patients had the mtDNA 11778 mutation with a mean age of 32.7 years at the onset of visual loss, whereas the mean age of other 43 patients was 21.2 years. One of these three patients was female. Conclusion: Antituberculosis medication may be an epigenetic factor of LHON in patients with a primary LHON mutation. This risk should be recognized by physicians and LHON carriers.
ISSN
1442-6404
Language
English
URI
http://hdl.handle.net/10371/76308
DOI
https://doi.org/10.1111/j.1442-9071.2010.02240.x
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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