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CXCL10 and autoimmune diseases

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dc.contributor.authorLee, Eun Young-
dc.contributor.authorLee, Zang-Hee-
dc.contributor.authorSong, Yeong Wook-
dc.date.accessioned2012-05-23T07:30:31Z-
dc.date.available2012-05-23T07:30:31Z-
dc.date.issued2009-03-
dc.identifier.citationAUTOIMMUNITY REVIEWS; Vol.8 5; 379-383ko_KR
dc.identifier.issn1568-9972-
dc.identifier.urihttps://hdl.handle.net/10371/76345-
dc.description.abstractCXCL10 is a 10 kDa protein, which is categorized functionally as a Th1-chemokine. It binds to the receptor CXCR3 and regulates immune responses through the activation and recruitment of leukocytes, such as, T cells, eosinophils, and monocytes. Recent reports have shown that serum and/or tissue expressions of CXCL10 are increased in various autoimmune diseases like rheumatoid arthritis (RA), systemic lupus rythematosus (SLE), Sjogren syndrome (SS), systemic sclerosis (SSc), and idiopathic inflammatory myopathy (IIM). Moreover, CXCL10 and CXCR3 may have important roles in leukocyte homing to inflamed tissues and in the perpetuation of inflammation, and therefore, tissue damage. Our recent study shows that CXCL10 also has a pathogenic role in bone destruction via receptor activator of NF-kappa B ligand (RANKL) induction in inflamed synovial tissue of RA. In addition to its chemotactic effect, CXCL10 may have pleiotropic functions. Further research on the function of this chemokine and interactions between CXCL10 and other cytokines and chemokines may provide therapeutic targets in various autoimmune diseases. (C) 2008 Elsevier B.V. All rights reserved.ko_KR
dc.description.sponsorshipThis work was supported by a grant from Korean Ministry of Education, Science and Technology (2008-05669).ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER SCIENCE BVko_KR
dc.subjectCXCL10ko_KR
dc.subjectAutoimmune diseaseko_KR
dc.subjectSystemic lupus erythematosusko_KR
dc.subjectRANKLko_KR
dc.subjectRheumatoid arthritisko_KR
dc.titleCXCL10 and autoimmune diseasesko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이은영-
dc.contributor.AlternativeAuthor이장희-
dc.contributor.AlternativeAuthor송영욱-
dc.identifier.doi10.1016/j.autrev.2008.12.002-
dc.citation.journaltitleAUTOIMMUNITY REVIEWS-
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