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Enhanced interleukin-2 diphtheria toxin conjugate-induced growth suppression in retinoic acid-treated hypoxic hepatocellular carcinoma cells

DC Field Value Language
dc.contributor.authorKim, Bo Hyun-
dc.contributor.authorYoon, Jung-Hwan-
dc.contributor.authorMyung, Sun Jung-
dc.contributor.authorLee, Jeong-Hoon-
dc.contributor.authorLee, Soo-Mi-
dc.contributor.authorLee, Hyo-Suk-
dc.contributor.authorLee, Sung-Hee-
dc.date.accessioned2012-05-24T00:33:29Z-
dc.date.available2012-05-24T00:33:29Z-
dc.date.issued2009-02-18-
dc.identifier.citationCANCER LETTERS; Vol.274 2; 259-265ko_KR
dc.identifier.issn0304-3835-
dc.identifier.urihttps://hdl.handle.net/10371/76363-
dc.description.abstractHypoxia induces survival signals in hepatocellular carcinoma (HCC). Hypoxia and retinoic acid (RA) may also induce interleukin-2 (IL-2) receptor expression, and thus we evaluated if RA and IL-2 receptor-targeted therapy are indicated in hypoxic HCCs. RA induced IL-2 receptor expression (R alpha, R beta, R gamma) in HCC cells, whereas hypoxia specifically induced IL-2 R gamma expression. IL-2 stimulated hypoxic HCC cell growth via p42/44 MAPK activation. Combination of denileukin diftitox and RA significantly suppressed hypoxic HCC cell growth compared to single agent-treated or normoxic cells. Therefore, denileukin diftitox and RA may be therapeutically implicated in infiltrative HCCs which are exposed to hypoxic environments. (C) 2008 Elsevier Ireland Ltd. All rights reserved.ko_KR
dc.description.sponsorshipThis study was supported by the Seoul National
University Hospital Research Fund (#03-2006-019) and the Korea Health
21 R&D Project (#0412-CR01-0704-0001).		ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectHypoxiako_KR
dc.subjectRetinoic acidko_KR
dc.subjectInterleukin-2ko_KR
dc.subjectInterleukin-2 diphteria toxin conjugateko_KR
dc.subjectHepatocellular carcinomako_KR
dc.titleEnhanced interleukin-2 diphtheria toxin conjugate-induced growth suppression in retinoic acid-treated hypoxic hepatocellular carcinoma cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김보현-
dc.contributor.AlternativeAuthor윤정환-
dc.contributor.AlternativeAuthor명선정-
dc.contributor.AlternativeAuthor이정훈-
dc.contributor.AlternativeAuthor이성희-
dc.contributor.AlternativeAuthor이수미-
dc.contributor.AlternativeAuthor이효석-
dc.identifier.doi10.1016/j.canlet.2008.09.025-
dc.citation.journaltitleCANCER LETTERS-
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dc.description.tc1-
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