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Suppression of Allergic Diarrhea in Murine Ovalbumin-Induced Allergic Diarrhea Model by PG102, a Water-Soluble Extract Prepared from Actinidia arguta
DC Field | Value | Language |
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dc.contributor.author | Kim, Donghyun | - |
dc.contributor.author | Kim, Seon Hee | - |
dc.contributor.author | Park, Eun-Jin | - |
dc.contributor.author | Kim, Jiyoung | - |
dc.contributor.author | Kagawa, Junko | - |
dc.contributor.author | Jun, Kunisawa | - |
dc.contributor.author | Kim, Sunyoung | - |
dc.contributor.author | Kiyono, Hiroshi | - |
dc.contributor.author | Arai, Naoko | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.date.accessioned | 2012-05-24T01:07:21Z | - |
dc.date.available | 2012-05-24T01:07:21Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY; Vol.150 2; 164-171 | ko_KR |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76373 | - |
dc.description.abstract | Background: Allergic reactions to food can involve diarrhea, vomiting, nausea and abnormal pain. PG102 has previously been shown to control various factors involved in allergy pathogenesis, including IgE and various Th1 and Th2 cytokines, in vivo as well as in vitro [Park EJ, et al.: J Allergy Clin Immunol 2005; 116: 1151-1157; Park EJ, et al.: J Invest Dermatol 2007; 127: 1154-1160]. These data indicate that PG102 might have antiallergic effects on allergic diarrhea. Here, we investigated whether PG102 could prevent allergic diarrhea in the murine ovalbumin (OVA)-induced allergic diarrhea model. Methods: BALB/c mice were orally treated with PG102, dexamethasone or water for 9 days on a daily basis, followed by subcutaneous injection with OVA on day 0. Animals were orally administrated with OVA from day 7, 3 times a week, over a period of approximately 20 days. Incidence of diarrhea, serum, OVA-restimulated splenocytes and lamina propria lymphocytes were analyzed. Results: Oral administration of PG102 could suppress the incidence of diarrhea in a murine allergic diarrhea model. The amelioration of allergic diarrhea by PG102 was accompanied with the inhibition of mast cell infiltration into the large intestine. The serum level of IgE, IL-6 and MCP-1 was decreased in PG102-treated mice. When splenocytes were isolated from respective groups and cultured in the presence of OVA, cells from PG102-administrated animals produced lesser amounts of IL-6 and MCP-1. Conclusions: PG102 has the potential to be used as a preventive for food allergic diseases. Copyright (C) 2009 S. Karger AG, Basel | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KARGER | ko_KR |
dc.subject | Actinidia arguta | ko_KR |
dc.subject | PG102 | ko_KR |
dc.subject | MCP-1 | ko_KR |
dc.subject | IL-10 | ko_KR |
dc.subject | IL-6 | ko_KR |
dc.subject | IgE | ko_KR |
dc.subject | Food allergy | ko_KR |
dc.subject | Diarrhea | ko_KR |
dc.subject | Antiallergy | ko_KR |
dc.title | Suppression of Allergic Diarrhea in Murine Ovalbumin-Induced Allergic Diarrhea Model by PG102, a Water-Soluble Extract Prepared from Actinidia arguta | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김동현 | - |
dc.contributor.AlternativeAuthor | 김선희 | - |
dc.contributor.AlternativeAuthor | 박은진 | - |
dc.contributor.AlternativeAuthor | 김지영 | - |
dc.contributor.AlternativeAuthor | 조상헌 | - |
dc.contributor.AlternativeAuthor | 김선영 | - |
dc.identifier.doi | 10.1159/000218119 | - |
dc.citation.journaltitle | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | - |
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dc.description.tc | 3 | - |
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