Publications
Detailed Information
Genetic Polymorphisms of Hypoxia-Inducible Factor-1 Alpha and Cardiovascular Disease in Hemodialysis Patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zheng, Zhen Lon | - |
dc.contributor.author | Hwang, Young-Hwan | - |
dc.contributor.author | Kim, Seong Kyun | - |
dc.contributor.author | Kim, Sejoong | - |
dc.contributor.author | Ro, Han | - |
dc.contributor.author | Lee, Hyun Hee | - |
dc.contributor.author | Joo, Kwon Wook | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.contributor.author | Chung, Woo Kyung | - |
dc.contributor.author | Sung, Su-Ah | - |
dc.contributor.author | Son, Min Jung | - |
dc.date.accessioned | 2012-05-24T01:38:12Z | - |
dc.date.available | 2012-05-24T01:38:12Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | NEPHRON CLINICAL PRACTICE; Vol.113 2; C104-C111 | ko_KR |
dc.identifier.issn | 1660-2110 | - |
dc.identifier.uri | https://hdl.handle.net/10371/76380 | - |
dc.description.abstract | Background: Hemodialysis patients are prone to ischemic events potentially aggravated by hypoxia. The key player in adaptation to hypoxia is hypoxia-inducible factor-1 alpha (HIF-1 alpha). Therefore, we investigated the association of HIF-1 alpha polymorphisms with ischemia/hypoxia-related events in hemodialysis patients. Methods: Patients on maintenance hemodialysis were enrolled from 4 training hospitals in Korea. Seven single nucleotide polymorphisms (SNP) of HIF-1 alpha were genotyped. The association of these SNP with hypoxia-related clinical outcomes (ischemic diseases and anemia) and cancer was analyzed. Results: A total of 376 patients participated in the study. No significant difference in genotype distribution was found between subjects with and without the hypoxia-related events. Three sets of linkage disequilibrium blocks were made for haplotype analyses (rs2783778 and rs7148720 in 5` upstream region; rs7143164 and rs10873142; rs2301113, rs11549465 and rs2057482). Of these, the CT haplotype in the first set was associated with both acute myocardial infarction and frequent intradialytic hypotension (acute myocardial infarction: adjusted odds ratio = 0.15, 95% CI: 0.03-0.69; frequent intradialytic hypotension: adjusted odds ratio = 0.29, 95% CI: 0.12-0.72). Conclusion: Genetic polymorphisms of HIF-1 alpha were associated with acute myocardial infarction and intradialytic hypotension in hemodialysis patients. Copyright (C) 2009 S. Karger AG, Basel | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KARGER | ko_KR |
dc.subject | Hemodialysis | ko_KR |
dc.subject | Hypoxia-inducible factor 1 | ko_KR |
dc.subject | Single nucleotide polymorphism | ko_KR |
dc.title | Genetic Polymorphisms of Hypoxia-Inducible Factor-1 Alpha and Cardiovascular Disease in Hemodialysis Patients | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 황영환 | - |
dc.contributor.AlternativeAuthor | 김성균 | - |
dc.contributor.AlternativeAuthor | 김세중 | - |
dc.contributor.AlternativeAuthor | 손민정 | - |
dc.contributor.AlternativeAuthor | 노한 | - |
dc.contributor.AlternativeAuthor | 성수아 | - |
dc.contributor.AlternativeAuthor | 이현희 | - |
dc.contributor.AlternativeAuthor | 정우경 | - |
dc.contributor.AlternativeAuthor | 주권욱 | - |
dc.contributor.AlternativeAuthor | 양재석 | - |
dc.identifier.doi | 10.1159/000228542 | - |
dc.citation.journaltitle | NEPHRON CLINICAL PRACTICE | - |
dc.description.citedreference | Rius J, 2008, NATURE, V453, P807, DOI 10.1038/nature06905 | - |
dc.description.citedreference | Percy MJ, 2008, NEW ENGL J MED, V358, P162 | - |
dc.description.citedreference | Nangaku M, 2007, J MOL MED-JMM, V85, P1325, DOI 10.1007/s00109-007-0278-y | - |
dc.description.citedreference | BelAiba RS, 2007, MOL BIOL CELL, V18, P4691, DOI 10.1091/mbc.E07-04-0391 | - |
dc.description.citedreference | Hlatky MA, 2007, AM HEART J, V154, P1035, DOI 10.1016/j.ahj.2007.07.042 | - |
dc.description.citedreference | Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795 | - |
dc.description.citedreference | Hong JM, 2007, OSTEOARTHR CARTILAGE, V15, P688, DOI 10.1016/j.joca.2006.12.007 | - |
dc.description.citedreference | Peng YJ, 2006, J PHYSIOL-LONDON, V577, P705, DOI 10.1113/jphysiol.2006.114033 | - |
dc.description.citedreference | Ke QD, 2006, MOL PHARMACOL, V70, P1469, DOI 10.1124/mol.106.027029 | - |
dc.description.citedreference | Imai E, 2006, KIDNEY INT, V69, P877, DOI 10.1038/sj.ki.5000088 | - |
dc.description.citedreference | Kido M, 2005, J AM COLL CARDIOL, V46, P2116, DOI 10.1016/j.jacc.2005.08.045 | - |
dc.description.citedreference | Yamada N, 2005, J CLIN ENDOCR METAB, V90, P5841, DOI 10.1210/jc.2005-0991 | - |
dc.description.citedreference | Kim JH, 2005, ONCOL REP, V13, P859 | - |
dc.description.citedreference | Ollerenshaw M, 2004, CANCER GENET CYTOGEN, V153, P122, DOI 10.1016/j.cancergencyto.2004.01.014 | - |
dc.description.citedreference | Herrero JA, 2002, RESP MED, V96, P487, DOI 10.1053/rmed.2002.1346 | - |
dc.description.citedreference | Elson DA, 2001, GENE DEV, V15, P2520 | - |
dc.description.citedreference | Vincent KA, 2000, CIRCULATION, V102, P2255 | - |
dc.description.citedreference | SUN MK, 1994, AM J PHYSIOL, V266, pR245 | - |
dc.description.citedreference | ROMALDINI H, 1984, AM REV RESPIR DIS, V129, P780 | - |
dc.description.tc | 1 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.