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Derivation of a new equation for estimating creatinine clearance by using fat-free mass and serum creatinine concentration in Korean patients with type 2 diabetes mellitus

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dc.contributor.authorLee, Eun Kyung-
dc.contributor.authorCho, Young Min-
dc.contributor.authorKim, Jin Taek-
dc.contributor.authorKoo, Bo Kyung-
dc.contributor.authorKu, Yun Hyi-
dc.contributor.authorJang, Hak Chul-
dc.contributor.authorLee, Hong Kyu-
dc.contributor.authorKim, Seong Yeon-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorCho, Hwa Young-
dc.date.accessioned2012-05-24T05:13:19Z-
dc.date.available2012-05-24T05:13:19Z-
dc.date.issued2009-01-
dc.identifier.citationDIABETES RESEARCH AND CLINICAL PRACTICE; Vol.83 1; 44-49ko_KR
dc.identifier.issn0168-8227-
dc.identifier.urihttps://hdl.handle.net/10371/76405-
dc.description.abstractAims: Equations to predict creatinine clearance (Ccr) or glomerular filtration rate have limitations in applying to a wide range of ethnicities with different fat-free mass (FFM). We aimed to determine the serum creatinine (Scr) concentrations that indicate renal insufficiency and formulate a new equation to estimate Ccr by a function of FFM in Korean type 2 diabetic patients. Methods: Ccr was measured in 283 type 2 diabetic patients by 24-h urine collection. Receiver operating characteristic (ROC) curve was used to determine the Scr concentration corresponding to a Ccr of 60 mL min(-1).1.73 m(-2). A new equation to predict Ccr was derived by using Scr and FFM. Results: The Scr concentration corresponding to a Ccr of 60 mL min(-1).1.73 m(-2) was 1. 15 mg/dL in men and 0.95 mg/dL in women. The regression equation estimating the Ccr was expressed as (1.72 x FFM - 0.23 x age)/Scr, and it showed a good correlation with the measured Ccr (r = 0.718, P < 0.001). Conclusions: Scr concentrations indicating renal insufficiency in the Korean patients were considerably lower than those in Caucasians. The equation derived in this study would be more useful in Korean or other Asian type 2 diabetic patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectFat-free massko_KR
dc.subjectType 2 diabetes mellitusko_KR
dc.subjectCreatinine clearanceko_KR
dc.titleDerivation of a new equation for estimating creatinine clearance by using fat-free mass and serum creatinine concentration in Korean patients with type 2 diabetes mellitusko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이은경-
dc.contributor.AlternativeAuthor조영민-
dc.contributor.AlternativeAuthor김진택-
dc.contributor.AlternativeAuthor구보경-
dc.contributor.AlternativeAuthor조화영-
dc.contributor.AlternativeAuthor구윤희-
dc.contributor.AlternativeAuthor박경수-
dc.contributor.AlternativeAuthor장학철-
dc.contributor.AlternativeAuthor김성연-
dc.contributor.AlternativeAuthor이홍규-
dc.identifier.doi10.1016/j.diabres.2008.09.047-
dc.citation.journaltitleDIABETES RESEARCH AND CLINICAL PRACTICE-
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